Differentiation of the gastric mucosa II. Role of gastrin in gastric epithelial cell proliferation and maturation

被引：38
作者：
Jain, Renu N. [1 ]
Samuelson, Linda C. [1 ]
机构：
[1] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2006年 / 291卷 / 05期
关键词：
stomach; gastric acid secretion; parietal cell; enterochromaffin-like cell; cholecystokinin-2; receptor;
D O I：
10.1152/ajpgi.00172.2006
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Gastrin is the principal hormonal inducer of gastric acid secretion. The cellular targets for gastrin in the stomach are the acid-secreting parietal cell and histamine-producing enterochromaffin-like (ECL) cell. Gastrin is also a growth factor, with hypergastrinemia resulting in increased proliferation of gastric progenitor cells and a thickened mucosa. This review presents insights into gastrin function revealed by genetically engineered mouse models, demonstrating a new role for gastrin in the maturation of parietal and ECL cells. Thus, gastrin regulates many aspects of gastric physiology, with tight regulation of gastrin levels required to maintain balanced growth and function of gastric epithelial cells.
引用
收藏
页码：G762 / G765
页数：4
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