A novel graded bioactive high adhesion implant coating

被引:47
作者
Brohede, Ulrika [1 ]
Zhao, Shuxi [2 ]
Lindberg, Fredrik [3 ]
Mihranyan, Albert [1 ]
Forsgren, Johan [1 ]
Stromme, Maria [1 ]
Engqvist, Hakan [3 ]
机构
[1] Uppsala Univ, Div Nanotechnol & Funct Mat, Dept Engn Sci, Angstrom Lab, S-75121 Uppsala, Sweden
[2] Uppsala Univ, Div Solid State Phys, Dept Engn Sci, Angstrom Lab, S-75121 Uppsala, Sweden
[3] Uppsala Univ, Div Mat Sci, Dept Engn Sci, Angstrom Lab, S-75121 Uppsala, Sweden
关键词
Implants; Coatings; Titanium oxide; XPS; XRD; TEM; Bioactivity; Adhesion; GRADIENT COATINGS; IN-VIVO; TITANIUM; SURFACE; DEPOSITION; OXIDATION; BIOMATERIALS; TIO2; FILM;
D O I
10.1016/j.apsusc.2009.04.149
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
One method to increase the clinical success rate of metal implants is to increase their bone bonding properties, i.e. to develop a bone bioactive surface leading to reduced risks of interfacial problems. Much research has been devoted to modifying the surface of metals to make them become bioactive. Many of the proposed methods include depositing a coating on the implant. However, there is a risk of coating failure due to low substrate adhesion. This paper describes a method to obtain bioactivity combined with a high coating adhesion via a gradient structure of the coating. Gradient coatings were deposited on Ti (grade 5) using reactive magnetron sputtering with increasing oxygen content. To increase the grain size in the coating, all coatings were post annealed at 385 degrees C. The obtained coating exhibited a gradual transition over 70 nm from crystalline titanium oxide (anatase) at the surface to metallic Ti in the substrate, as shown using cross-section transmission electron microscopy and X-ray photoelectron spectroscopy depth pro. ling. Using scratch testing, it could be shown that the adhesion to the substrate was well above 1 GPa. The bioactivity of the coating was verified in vitro by the spontaneous formation of hydroxylapatite upon storage in phosphate buffer solution at 37 degrees C for one week. The described process can be applied to implants irrespective of bulk metal in the base and should introduce the possibility to create safer permanent implants like reconstructive devices, dental, or spinal implants. (C) 2009 Elsevier B. V. All rights reserved.
引用
收藏
页码:7723 / 7728
页数:6
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