Influence of Microencapsulation Process Parameters on Naltrexone Prolonged-Release Dosage Form

被引：4

作者：

Petrova, E. A. ^{[1
]}

Kedik, S. A. ^{[1
]}

Alekseev, K. V. ^{[1
]}

Blynskaya, E. V. ^{[1
]}

Panov, A. V. ^{[1
]}

Suslov, V. V. ^{[1
]}

Tikhonova, N. V. ^{[1
]}

机构：

[1] Inst Pharmaceut Technol, Moscow 119571, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 48卷 / 01期

关键词：

naltrexone; microspheres; copolymer of lactic and glycolic acids (PLGA);

D O I：

10.1007/s11094-014-1048-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The quality parameters of naltrexone microspheres based on the copolymer of lactic and glycolic acids (PLGA) were established as a function of the microencapsulation process parameters. The release profile of the developed naltrexone dosage form was found to coincide with that of the reference drug Vivitrol. The results were interesting scientifically and could be used to develop technology for producing generic Vivitrol.

引用

页码：65 / 68

页数：4

共 4 条

[1] Vivitrex®, an injectable, extended-release formulation of naltrexone, provides pharmacokinetic and pharmacodynamic evidence of efficacy for 1 month in rats [J].