Transition-metal-free regioselective thiocyanation of phenols, anilines and heterocycles

被引：52
|
作者：
Mete, Trimbak B. [1 ]
Khopade, Tushar M. [1 ]
Bhat, Ramakrishna G. [1 ]
机构：
[1] IISER, Dept Chem, Pune 411008, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 05期
关键词：
Thiocyanation; Transition-metal-free; Persulphate; Radical cation; Radical scavenger; ARYL THIOCYANATES; HETEROAROMATIC-COMPOUNDS; LEAD(II) THIOCYANATE; ORGANIC THIOCYANATES; C-3; THIOCYANATION; AMMONIUM-NITRATE; CATION RADICALS; ROUTE; SUBSTITUTION; OXIDATION;
D O I：
10.1016/j.tetlet.2016.12.043
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An expedient direct and regioselective thiocyanation of phenols, anilines and heterocycles is described. Transformation is realized via the direct C-H functionalization under transition metal free conditions at ambient temperature in excellent yields. Method proved to be monoselective and variety of functional groups tolerated the reaction conditions. The practicality of the protocol is demonstrated in gram scale synthesis of a precursor of PPAR delta agonist in excellent yield. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：415 / 418
页数：4
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