Caenorhabditis elegans senses bacterial autoinducers

被引：85

作者：

Beale, Elmus

Li, Guigen

Tan, Man-Wah

Rumbaugh, Kendra P.

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Dept Surg, Lubbock, TX 79430 USA

[2] Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430 USA

[3] Texas Tech Univ, Dept Biochem, Lubbock, TX 79430 USA

[4] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2006年 / 72卷 / 07期

关键词：

D O I：

10.1128/AEM.00611-06

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pseudomonas aeruginosa uses virulence factors controlled by quorum sensing (QS) to kill Caenorhabditis elegans. Here we show that C. elegans is attracted to the acylated homoserine lactones (AHSLs) that mediate QS in P. aeruginosa. Our data also indicate that C. elegans can distinguish AHSLs and may use them to mediate aversive or attractive learning.

引用

收藏

页码：5135 / 5137

页数：3

相关论文

共 16 条

[1] Characterization of mediators of microbial virulence and innate immunity using the Caenorhabditis elegans host-pathogen model [J].

Alegado, RA ;

Campbell, MC ;

Chen, WC ;

Slutz, SS ;

Tan, MW .

CELLULAR MICROBIOLOGY, 2003, 5 (07) :435-444

[2] ODORANT-SELECTIVE GENES AND NEURONS MEDIATE OLFACTION IN C-ELEGANS [J].

BARGMANN, CI ;

HARTWIEG, E ;

HORVITZ, HR .

CELL, 1993, 74 (03) :515-527

[3] A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry:: application ito a model bacterial biofilm [J].

Charlton, TS ;

de Nys, R ;

Netting, A ;

Kumar, N ;

Hentzer, M ;

Givskov, M ;

Kjelleberg, S .

ENVIRONMENTAL MICROBIOLOGY, 2000, 2 (05) :530-541

[4] Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators [J].

Chhabra, SR ;

Harty, C ;

Hooi, DSW ;

Daykin, M ;

Williams, P ;

Telford, G ;

Pritchard, DI ;

Bycroft, BW .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (01) :97-104

[5] A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling [J].

Chuang, CF ;

Bargmann, CI .

GENES & DEVELOPMENT, 2005, 19 (02) :270-281

[6] Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa [J].

Darby, C ;

Cosma, CL ;

Thomas, JH ;

Manoil, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15202-15207

[7] Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning [J].

Gallagher, LA ;

Manoil, C .

JOURNAL OF BACTERIOLOGY, 2001, 183 (21) :6207-6214

[8] Serotonin mediates food-odor associative learning in the nematode Caenorhabditis elegans [J].

Nuttley, WM ;

Atkinson-Leadbeater, KP ;

van der Kooy, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (19) :12449-12454

[9] Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes [J].

Pearson, JP ;

Pesci, EC ;

Iglewski, BH .

JOURNAL OF BACTERIOLOGY, 1997, 179 (18) :5756-5767

[10] STRUCTURE OF THE AUTOINDUCER REQUIRED FOR EXPRESSION OF PSEUDOMONAS-AERUGINOSA VIRULENCE GENES [J].

PEARSON, JP ;

GRAY, KM ;

PASSADOR, L ;

TUCKER, KD ;

EBERHARD, A ;

IGLEWSKI, BH ;

GREENBERG, EP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) :197-201