Synthesis of Enantioenriched Secondary and Tertiary Alcohols via Tricarbonylchromium(0) Complexes of Benzyl Allyl Ethers

被引：6

作者：

Abecassis, Keren ^{[1
]}

Gibson, Susan E. ^{[1
]}

Martin-Fontecha, Mar ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

Alcohols; Allylic compounds; Chiral base; Chromium; Enantioselectivity; Alkylation; CHIRALITY; CORE;

D O I：

10.1002/ejoc.200900007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Allyl ethers of the tricarbonylchromium(0) complexes of benzylic alcohols undergo highly enantioselective benzylic functionalisation using a chiral base/electrophilic quench sequence; the allyl group is readily removed to reveal a hy-droxy group as demonstrated in the syntheses of enantioenriched imidazole alcohols, a triol and a tertiary alcohol. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

引用

页码：1606 / 1611

页数：6

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