Synthesis of Enantioenriched Secondary and Tertiary Alcohols via Tricarbonylchromium(0) Complexes of Benzyl Allyl Ethers

被引：6
|
作者：
Abecassis, Keren [1 ]
Gibson, Susan E. [1 ]
Martin-Fontecha, Mar [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 10期
基金：
英国工程与自然科学研究理事会;
关键词：
Alcohols; Allylic compounds; Chiral base; Chromium; Enantioselectivity; Alkylation; CHIRALITY; CORE;
D O I：
10.1002/ejoc.200900007
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Allyl ethers of the tricarbonylchromium(0) complexes of benzylic alcohols undergo highly enantioselective benzylic functionalisation using a chiral base/electrophilic quench sequence; the allyl group is readily removed to reveal a hy-droxy group as demonstrated in the syntheses of enantioenriched imidazole alcohols, a triol and a tertiary alcohol. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
引用
收藏
页码：1606 / 1611
页数：6
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