All-natural composite wound dressing films of essential oils encapsulated in sodium alginate with antimicrobial properties

被引：219

作者：

Liakos, Ioannis ^{[1
]}

Rizzello, Loris ^{[2
]}

Scurr, David J. ^{[3
]}

Pompa, Pier Paolo ^{[2
]}

Bayer, Ilker S. ^{[1
]}

Athanassiou, Athanassia ^{[1
]}

机构：

[1] Ist Italiano Tecnol, I-16163 Genoa, Italy

[2] Ist Italiano Tecnol UniLe, Ctr Biomol Nanotechnol, I-73010 Lecce, Italy

[3] Univ Nottingham, Sch Pharm Biophys & Surface Anal, Nottingham NG7 2RD, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2014年 / 463卷 / 02期

关键词：

Antimicrobial wound dressings; Natural materials; Essential oils; Sodium alginate; Surface analysis; ANTIBACTERIAL PROPERTIES; NANOFIBER MATS; CHITOSAN; RELEASE; GEL;

D O I：

10.1016/j.ijpharm.2013.10.046

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We present natural polymeric composite films made of essential oils (EOs) dispersed in sodium alginate (NaAlg) matrix, with remarkable anti-microbial and anti-fungal properties. Namely, elicriso italic, chamomile blue, cinnamon, lavender, tea tree, peppermint, eucalyptus, lemongrass and lemon oils were encapsulated in the films as potential active substances. Glycerol was used to induce plasticity and surfactants were added to improve the dispersion of EOs in the NaAlg matrix. The topography, chemical composition, mechanical properties, and humidity resistance of the films are presented analytically. Antimicrobial tests were conducted on films containing different percentages of EOs against Escherichia coli bacteria and Candida albicans fungi, and the films were characterized as effective or not. Such diverse types of essential oil-fortified alginate films can find many applications mainly as disposable wound dressings but also in food packaging, medical device protection and disinfection, and indoor air quality improvement materials, to name a few. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：137 / 145

页数：9

共 33 条

[1]

Abdelrahman T., 2011, SURG OXFORD, V29, P491, DOI DOI 10.1016/J.MPSUR.2011.06.007

[2] Modified wound dressing with phyto-nanostructured coating to prevent staphylococcal and pseudomonal biofilm development [J].