Multi-hull ships are growing rapidly to respond the challenge for larger load capacity yet having lower fuel consumption. Advantages of pentamaran ship are the need for lower power, loss of speed due to wave is lower, and very good of seakeeping characteristics. This study aimed to determine the effect of variations in separation and staggered of side hull II (outer side hulls) to the total resistances to get the configuration with the lowest resistance interference. Configuration was varied by adjust the separation position. Method of towing carriage experiments are used with variations of Fr from 0.10 to 0.70. Conclusion, the effect of side hull II (outer side hulls) position either separation or staggered give different characteristic on resistance depend on the value of Fr. The analysis in high range of Fr describes while side hull II adjusted the closer separation, the higher total resistance occurred. At high speed II.a configuration (S/L = 75/200, R/L = 1/20) gives favorable drag reduction with maximum 22.65% in Fr around 0.55. (C) 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of the organizing committee of the 10th International Conference on Marine Technology.