Poly(PEGA)-b-poly(L-lysine)-b-poly(L-histidine) Hybrid Vesicles for Tumoral pH-Triggered Intracellular Delivery of Doxorubicin Hydrochloride

被引：63

作者：

Johnson, Renjith P. ^{[1
]}

Uthaman, Saji ^{[3
,4
]}

John, Johnson V. ^{[1
]}

Lee, Hye Ri ^{[1
]}

Lee, Sang Joon ^{[3
,4
]}

Park, Huiju ^{[1
]}

Park, In-Kyu ^{[3
,4
]}

Suh, Hongsuk ^{[2
]}

Kim, Il ^{[1
]}

机构：

[1] Pusan Natl Univ, Dept Polymer Sci & Engn, BK PLUS Ctr Adv Chem Technol 21, Pusan 609735, South Korea

[2] Pusan Natl Univ, Inst Funct Mat, Dept Chem & Chem, Pusan 609735, South Korea

[3] Chonnam Natl Univ, Sch Med, Dept Biomed Sci, Gwangju 501746, South Korea

[4] Chonnam Natl Univ, BK PLUS Ctr Creat Biomed Scientists 21, Gwangju 501746, South Korea

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 39期

基金：

新加坡国家研究基金会;

关键词：

biocompatible polymer; self-assembly; nanovesicles; pH-responsive; anticancer drug delivery; BLOCK-COPOLYMER VESICLES; POLYPEPTIDE DIBLOCK COPOLYMERS; DRUG-DELIVERY; BIODEGRADABLE POLYMERSOMES; RADICAL POLYMERIZATION; MICELLES; LIPOSOMES; RELEASE; WATER; NANOPARTICLES;

D O I：

10.1021/acsami.5b05338

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A series of poly(ethylene glycol) methyl ether acrylate-block-poly(L-lysine)-block-poly(L-histidine) [p(PEGA)(30)-b-p(Lys)(25)-b-p(His)(n)] (n = 25, 50, 75, 100) triblock copolypeptides were designed and synthesized for tumoral pH-responsive intracellular release of anticancer drug doxorubicin hydrochloride (Dox). The tumoral acidic pH-responsive hybrid vesicles fabricated were stable at physiological pH 7.4 and could gradually destabilize in acidic pH as a result of pH-induced swelling of the p(His) block. The blank vesicles were nontoxic over a wide concentration range (0.01-100 mu g/mL) in normal cell lines. The tumor acidic pH responsiveness of these vesicles was exploited for intracellular delivery of fox. Vesicles efficiently encapsulated Dox, and pH-induced destabilization resulted in the controlled and sustained release of Dox in CT26 murine cancer cells, and dose-dependent cytotoxicity. The tumor-specific controlled release fox from vesicles demonstrates this system represents a promising theranostic agent for tumor-targeted delivery.

引用

页码：21770 / 21779

页数：10

共 62 条

[1] pH and Temperature Responsive Polymeric Micelles and Polymersomes by Self-Assembly of Poly[2-(dimethylamino)ethyl methacrylate]-b-Poly(glutamic acid) Double Hydrophilic Block Copolymers [J].