Treatment of bone and joint infections caused by Enterobacter cloacae with a fluoroquinolone-cotrimoxazole combination

被引：8

作者：

Cisse, Hawa ^{[1
]}

Vernet-Garnier, Veronique ^{[2
]}

Hentzien, Maxime ^{[1
]}

Bajolet, Odile ^{[3
]}

Lebrun, Delphine ^{[4
]}

Bonnet, Morgane ^{[5
]}

Ohl, Xavier ^{[6
]}

Diallo, Saidou ^{[6
]}

Bani-Sadr, Firouze ^{[1
]}

机构：

[1] Reims Teaching Hosp, Dept Internal Med & Infect Dis, Reims, France

[2] Reims Teaching Hosp, Dept Bacteriol, Reims, France

[3] Reims Teaching Hosp, Dept Hyg, Reims, France

[4] Manchester Hosp, Dept Internal Med & Infect Dis, Charleville Mezieres, France

[5] Reims Teaching Hosp, Dept Pharm, Reims, France

[6] Reims Teaching Hosp, Dept Orthopaed Surg, Reims, France

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2019年 / 54卷 / 02期

关键词：

Bone infection; Enterobacter spp; Enterobacter cloacae; Fluoroquinolone-cotrimoxazole combination; Fluoroquinolone; Cotrimoxazole; GRAM-NEGATIVE BACILLI; RISK-FACTORS; TRIMETHOPRIM; OSTEOMYELITIS; RIFAMPIN; THERAPY;

D O I：

10.1016/j.ijantimicag.2019.05.010

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Although the frequency of bone and joint infections caused by Enterobacter spp. is increasing, studies regarding the optimal antibiotic therapy are scarce. The objective of this retrospective study was to assess the clinical outcomes and safety of a fluoroquinolone-cotrimoxazole combination for the treatment of bone and joint infections caused by Enterobacter cloacae. Between 2010 and 2017, 30 patients with bone and joint infections caused by E. cloacae were treated with a fluoroquinolone-cotrimoxazole combination for 8-12 weeks. There were 26 cases (87%) of infection of an internal fixation device, two cases (6.6%) of pseudarthrosis with chronic osteomyelitis, and two cases (6.6%) of infection of knee and ankle prosthetic devices. The cure rate of the fluoroquinolone-cotrimoxazole combination was 80% by intention-to-treat analysis, with a mean follow-up of 29.3 +/- 19.1 months. The fluoroquinolone-cotrimoxazole combination for 8-12 weeks is effective for the treatment of bone and joint infections caused by E. cloacae. (C) 2019 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

引用

页码：245 / 248

页数：4

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