Comparison of the EUCAST and CLSI Broth Microdilution Methods for Testing Isavuconazole, Posaconazole, and Amphotericin B against Molecularly Identified Mucorales Species

被引：43

作者：

Chowdhary, Anuradha ^{[1
]}

Singh, Pradeep Kumar ^{[1
]}

Kathuria, Shallu ^{[1
]}

Hagen, Ferry ^{[2
]}

Meis, Jacques F. ^{[2
,3
]}

机构：

[1] Univ Delhi, Vallabhbhai Patel Chest Inst, Dept Med Mycol, Delhi 110007, India

[2] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

[3] Radboudumc, Dept Med Microbiol, Nijmegen, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 12期

关键词：

ANTIFUNGAL SUSCEPTIBILITY; MUCORMYCOSIS; MANAGEMENT; DIAGNOSIS; BEDSIDE; BENCH;

D O I：

10.1128/AAC.02107-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We compared EUCAST and CLSI antifungal susceptibility testing (AFST) methods for triazoles and amphotericin B against 124 clinical Mucorales isolates. The EUCAST method yielded MIC values 1- to 3-fold dilutions higher than those of the CLSI method for amphotericin B. The essential agreements between the two methods for triazoles were high, i.e., 99.1% (voriconazole), 98.3% (isavuconazole), and 87% (posaconazole), whereas it was significantly lower for amphotericin B (66.1%). Strategies for harmonization of the two methods for Mucorales AFST are warranted.

引用

页码：7882 / 7887

页数：6

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