Gut biogeography of the bacterial microbiota

被引：1704

作者：

Donaldson, Gregory P. ^{[1
]}

Lee, S. Melanie ^{[1
]}

Mazmanian, Sarkis K. ^{[1
]}

机构：

[1] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2016年 / 14卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

SEGMENTED FILAMENTOUS BACTERIA; INTESTINAL MICROBIOTA; SPATIAL-ORGANIZATION; ESCHERICHIA-COLI; FECAL MICROBIOTA; CROHNS-DISEASE; HEPATIC-ENCEPHALOPATHY; IMMUNOGLOBULIN-A; HOST INTERACTION; MUCOSAL FLORA;

D O I：

10.1038/nrmicro3552

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Animals assemble and maintain a diverse but host-specific gut microbial community. In addition to characteristic microbial compositions along the longitudinal axis of the intestines, discrete bacterial communities form in microhabitats, such as the gut lumen, colonic mucus layers and colonic crypts. In this Review, we examine how the spatial distribution of symbiotic bacteria among physical niches in the gut affects the development and maintenance of a resilient microbial ecosystem. We consider novel hypotheses for how nutrient selection, immune activation and other mechanisms control the biogeography of bacteria in the gut, and we discuss the relevance of this spatial heterogeneity to health and disease.

引用

页码：20 / 32

页数：13

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