Iodine-catalyzed chemoselective dehydrogenation and aromatization of tetrahydro-β-carbolines: A short synthesis of Kumujian-C, Eudistomin-U, Norharmane, Harmane Harmalan and Isoeudistomine-M

被引：26
作者：
Gaikwad, Sunil [1 ]
Kamble, Dayanand [1 ]
Lokhande, Pradeep [1 ]
机构：
[1] Savitribai Phule Pune Univ, Ctr Adv Studies, Dept Chem, Pune 411007, Maharashtra, India
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 25期
关键词：
Dehydrogenation; Aromatization; Iodine; Carbolines; Kumujian-C; Eudistomin-U; BIOLOGICAL EVALUATION; CARBAZOLE ALKALOIDS; EFFICIENT SYNTHESIS; ROOM-TEMPERATURE; FORMAL SYNTHESIS; DERIVATIVES; UTILITY; DESIGN; HETEROCYCLES; CYCLIZATION;
D O I：
10.1016/j.tetlet.2018.04.043
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Temperature controlled chemoselective dehydrogenation and aromatization of tetrahydro-beta-carbolines, using molecular I-2 and H2O2, in DMSO solvent affords a practical access to a series of corresponding 3,4-dihydro-beta-carbolines and beta-carbolines respectively. This method has been successfully employed in the short synthesis of Kumujian-C, Eudistomin-U, Norharmane Harmane Harmalan and Isoeudistomin-M. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2387 / 2392
页数：6
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