Complex differential variance algorithm for optical coherence tomography angiography

被引：85
作者：
Nam, Ahhyun S. [1 ,2 ]
Chico-Calero, Isabel [2 ,3 ]
Vakoc, Benjamin J. [2 ,3 ,4 ]
机构：
[1] MIT, Dept Mech Engn, Cambridge, MA 02139 USA
[2] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
[4] Harvard Mit Div Hlth Sci & Technol, Dept Hlth Sci & Technol, Cambridge, MA 02139 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 11期
基金：
美国国家卫生研究院;
关键词：
SWEPT SEMICONDUCTOR-LASER; BLOOD-FLOW; INTENSITY; CONTRAST; OCT;
D O I：
10.1364/BOE.5.003822
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We describe a complex differential variance (CDV) algorithm for optical coherence tomography based angiography. The algorithm exploits both the intensity and phase changes of optical coherence tomography (OCT) signals from flowing blood to achieve high vascular contrast, and also intrinsically reject undesirable phase signals originating from small displacement axial bulk tissue motion and instrument synchronization errors. We present this algorithm within a broader discussion of the properties of OCT signal dynamics. The performance of the algorithm is compared against two other existing algorithms using both phantom measurements and in vivo data. We show that the algorithm provides better contrast for a given number of measurements and equivalent spatial averaging. (C) 2014 Optical Society of America
引用
收藏
页码：3822 / 3832
页数：11
相关论文
共 23 条
[1]   Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds [J].
An, Lin ;
Qin, Jia ;
Wang, Ruikang K. .
OPTICS EXPRESS, 2010, 18 (08) :8220-8228
[2]   In situ structural and microangiographic assessment of human skin lesions with high-speed OCT [J].
Blatter, Cedric ;
Weingast, Jessika ;
Alex, Aneesh ;
Grajciar, Branislav ;
Wieser, Wolfgang ;
Drexler, Wolfgang ;
Huber, Robert ;
Leitgeb, Rainer A. .
BIOMEDICAL OPTICS EXPRESS, 2012, 3 (10) :2636-2646
[3]   Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans [J].
Braaf, Boy ;
Vermeer, Koenraad A. ;
Vienola, Kari V. ;
de Boer, Johannes F. .
OPTICS EXPRESS, 2012, 20 (18) :20516-20534
[4]   Phase-stabilized optical frequency domain imaging at 1-μm for the measurement of blood flow in the human choroid [J].
Braaf, Boy ;
Vermeer, Kocnraad A. ;
Sicam, Victor Arni D. P. ;
van Zeeburg, Elsbeth ;
van Meurs, Jan C. ;
de Boer, Johannes F. .
OPTICS EXPRESS, 2011, 19 (21) :20886-20903
[5]   Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography [J].
Fingler, Jeff ;
Schwartz, Dan ;
Yang, Changhuei ;
Fraser, Scott E. .
OPTICS EXPRESS, 2007, 15 (20) :12636-12653
[6]   A comparison of Doppler optical coherence tomography methods [J].
Liu, Gangjun ;
Lin, Alexander J. ;
Tromberg, Bruce J. ;
Chen, Zhongping .
BIOMEDICAL OPTICS EXPRESS, 2012, 3 (10) :2669-2680
[7]   Intensity-based modified Doppler variance algorithm: application to phase instable and phase stable optical coherence tomography systems [J].
Liu, Gangjun ;
Chou, Lidek ;
Jia, Wangcun ;
Qi, Wenjuan ;
Choi, Bernard ;
Chen, Zhongping .
OPTICS EXPRESS, 2011, 19 (12) :11429-11440
[8]   Optical coherence angiography [J].
Makita, Shuichi ;
Hong, Youngjoo ;
Yamanari, Masahiro ;
Yatagai, Toyohiko ;
Yasuno, Yoshiaki .
OPTICS EXPRESS, 2006, 14 (17) :7821-7840
[9]   Speckle variance detection of microvasculature using swept-source optical coherence tomography [J].
Mariampillai, Adrian ;
Standish, Beau A. ;
Moriyama, Eduardo H. ;
Khurana, Mamta ;
Munce, Nigel R. ;
Leung, Michael K. K. ;
Jiang, James ;
Cable, Alex ;
Wilson, Brian C. ;
Vitkin, I. Alex ;
Yang, Victor X. D. .
OPTICS LETTERS, 2008, 33 (13) :1530-1532
[10]   In vivo imaging of the diseased nervous system [J].
Misgeld, Thomas ;
Kerschensteiner, Martin .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (06) :449-463
123