Cytotoxic steroidal saponins from the roots and rhizomes of Maianthemum henryi

被引：1

作者：

Zhang, Xin ^{[1
,2
]}

Sun, Jing ^{[2
]}

Zhang, Xiaofei ^{[2
]}

Zhang, Shuo ^{[3
]}

Zhang, Xuan ^{[4
]}

Xue, Xuanji ^{[1
,5
]}

Guo, Zengjun ^{[1
,5
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Pharm, Xian, Shaanxi, Peoples R China

[2] Shaanxi Univ Chinese Med, Sch Pharm, Xianyang, Peoples R China

[3] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China

[4] Shaanxi Univ Chinese Med, Affiliated Hosp 2, Xianyang, Peoples R China

[5] Shaanxi Key Lab Qiyao Resources & Antitumor Acit, Xian, Shaanxi, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 11期

关键词：

Maianthemum henryi; henryioside F; henryioside G; structure determination; cytotoxicity; GLYCOSIDES;

D O I：

10.1080/14786419.2019.1641812

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Henryiosides F and G (1 and 2), two new steroidal saponins along with two known analogues (3 and 4) were obtained from the roots and rhizomes of Maianthemum henryi. Their structures were determined by physicochemical properties and spectroscopic methods including 1D, 2D-NMR, IR and HR-ESI-MS data analysis. Cytotoxic activity in human HepG2 and SW620 tumour cells were evaluated by the MTT method and all of the saponins exhibited cytotoxicity with IC50 values ranging from 15.33 mu M to 57.85 mu M. [GRAPHICS] .

引用

页码：1808 / 1815

页数：8

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