Flow-injection chemiluminescence method for the determination of naphazoline hydrochloride and oxymetazoline hydrochloride

被引：15

作者：

Wang, Nan-Nan ^{[1
]}

Sha, Yan-Qing ^{[1
]}

Tang, Yu-Hai ^{[2
]}

Yin, He-Ping ^{[1
]}

Wu, Xiao-Zhong ^{[1
]}

机构：

[1] Second Affiliated Hosp, Dept Medicament, Inner Mongolia Med Coll, Hohhot 010030, Peoples R China

[2] Xi An Jiao Tong Univ, Inst Analyt Chem, Xian 710061, Peoples R China

来源：

LUMINESCENCE | 2009年 / 24卷 / 03期

关键词：

flow-injection; chemiluminescence; naphazoline hydrochloride; oxymetazoline hydrochloride; NEURAL NETWORKS;

D O I：

10.1002/bio.1092

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive and simple flow-injection chemiluminescence (FI-CL) method, which was based on the CL intensity generated from the redoxreaction of potassium permanganate (KMnO4)-formaldehyde in vitriol (H2SO4) medium, has been developed, validated and applied for the determination of naphazoline hydrochloride and oxymetazoline hydrochloride. Besides oxidants and sensitizers, the effect of the concentration of H2SO4, KMnO4, and formaldehyde was investigated. Under the optimum conditions, the linear range was 1.0 x 10(-2)-7.0 mg/L for naphazoline hydrochloride and 5.0 x 10(-2)-10.0 mg/L for oxymetazoline hydrochloride. During seven repeated inter-day and intra-day precision tests of 0.1, 1.0 and 10.0 mg/L samples, the relative standard deviations all corresponded to reference values. The detection limit was 8.69 x 10(-3) mg/L for naphazoline hydrochloride and 3.47 x 10(-2) mg/L for oxymetazoline hydrochloride (signal-to-noise ratio <= 3). This method has been successfully implemented for the determination of naphazoline hydrochloride and oxymetazoline hydrochloride in pharmaceuticals. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：178 / 182

页数：5

共 11 条

[1] Comparison of three different phosphorescent methodologies in solution for the analysis of naphazoline in pharmaceutical preparations [J].

Díaz, BC ;

Terrones, SC ;

Carretero, AS ;

Fernández, JMC ;

Gutiérrez, AF .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2004, 379 (01) :30-34

[2] Flow injection analysis of oxymetazoline hydrochloride with inhibited chemiluminescent detection [J].

García-Campaña, AM ;

Sendra, JMB ;

Vargas, MPB ;

Baeyens, WRG ;

Zhang, XR .

ANALYTICA CHIMICA ACTA, 2004, 516 (1-2) :245-249

[3] A novel naphazoline-selective membrane sensor and its pharmaceutical applications [J].

Ghoreishi, SM ;

Behpour, M ;

Nabi, M .

SENSORS AND ACTUATORS B-CHEMICAL, 2006, 113 (02) :963-969

[4] Complementary use of partial least-squares and artificial neural networks for the non-linear spectrophotometric analysis of pharmaceutical samples [J].

Goicoechea, HC ;

Collado, MS ;

Satuf, ML ;

Olivieri, AC .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2002, 374 (03) :460-465

[5] Net analyte signal-based simultaneous determination of antazoline and naphazoline using wavelength region selection by experimental design-neural networks [J].

Hemmateenejad, A ;

Ghavami, R ;

Miri, R ;

Shamsipur, M .

TALANTA, 2006, 68 (04) :1222-1229

[6]

Jiang X., 2003, DRUG STANDARDS CHINA, V4, P63

[7]

LI F, 2002, J PHARM ANAL CHINA, V22, P200

[8] Simultaneous determination of naphazoline, diphenhydramine and phenylephrine in nasal solutions by capillary electrophoresis [J].

Marchesini, AF ;

Williner, MR ;

Mantovani, VE ;

Robles, JC ;

Goicoechea, HC .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2003, 31 (01) :39-46

[9]

SABRY K, 1999, MIKROCHIM ACTA, V130, P181

[10] Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC [J].

Sudsakorn, S ;

Kaplan, L ;

Williams, DA .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 40 (05) :1273-1280

← 1 2 →