Impingement of metal-polyethylene hip prostheses Potential cause of high systemic titanium levels?

High blood metal levels have been described in the past, primarily in metal-on-metal bearings. Other possible causes are often underestimated. This report presents the case of a 70-year-old female patient who suffered from pronounced neurological symptoms (especially fatigue and concentration problems) 13 years after implantation of a hip endoprosthesis with metal-polyethylene (ME-PE) bearing. An osteolysis in the pelvis and loosening of the acetabular component were detected. In addition, large quantities of metallic black discolored granulomas were detected in the periarticular environment during surgery. A ventral impingement with destruction of the titanium cup and the PE insert was identified as the suspected cause of this condition. The postoperative course of the blood metal levels was unexpected as titanium levels increased massively in the blood. Anamnesis, course of the disease and the surgical procedure as well as especially the course of the metal values in the blood of the patient are presented. Possible causes for the excessive occurrence of metal abrasion, the systemic distribution and potential toxic effects of titanium are explained and discussed in detail. In addition, the currently available literature on the subject is critically examined.