An economic review of compliance with medication therapy in the treatment of schizophrenia

被引:141
作者
Thieda, P
Beard, S
Richter, A
Kane, J
机构
[1] RTI Hlth Solut, Res Triangle Pk, NC 27709 USA
[2] RTI Hlth Solut, Manchester, Lancs, England
[3] Long Isl Jewish Med Ctr, Hillside Hosp, Dept Psychiat, Glen Oaks, NY 11004 USA
[4] Albert Einstein Coll Med, Dept Psychiat, Bronx, NY 10467 USA
关键词
D O I
10.1176/appi.ps.54.4.508
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objectives: The authors examined published economic evaluations of schizophrenia and antipsychotic therapies to determine the role of compliance with medication therapy in the economic cost of schizophrenia. Methods: The authors reviewed studies published from 1995 to 2002 that evaluated compliance with treatment for schizophrenia. Literature searches were conducted for that period by using MEDLINE, EM-BASE, and Current Contents. The primary search terms were "schizophrenia," 'compliance," "relapse," and "economic costs." Results and conclusions: A definitive relationship exists between compliance and the economic costs of schizophrenia. Lower rates of compliance lead to higher costs of treating schizophrenia. However, the full implications are difficult to surmise from the literature because of inadequacies in the reporting of compliance rates and outcomes of treatment over time. The authors suggest collection of data on longer-term clinical outcomes as a means to improve future economic evaluations of schizophrenia treatments.
引用
收藏
页码:508 / 516
页数:9
相关论文
共 30 条
[1]   Cost analysis of the treatment of schizophrenia in the UK - A simulation model comparing olanzapine, risperidone and haloperidol [J].
Almond, S ;
O'Donnell, O .
PHARMACOECONOMICS, 2000, 17 (04) :383-389
[2]  
Carter CS, 1995, PSYCHOPHARMACOL BULL, V31, P719
[3]   Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: A review and meta-analysis of randomized trials [J].
Chakos, M ;
Lieberman, J ;
Hoffman, E ;
Bradford, D ;
Sheitman, B .
AMERICAN JOURNAL OF PSYCHIATRY, 2001, 158 (04) :518-526
[4]   Compliance with medication regimens for mental and physical disorders [J].
Cramer, JA ;
Rosenheck, R .
PSYCHIATRIC SERVICES, 1998, 49 (02) :196-201
[5]   Risperidone versus haloperidol: II. Cost-effectiveness [J].
Davies, A ;
Langley, PC ;
Keks, NA ;
Catts, SV ;
Lambert, T ;
Schweitzer, I .
CLINICAL THERAPEUTICS, 1998, 20 (01) :196-213
[6]   Dual diagnosis of substance abuse in schizophrenia: prevalence and impact on outcomes [J].
Dixon, L .
SCHIZOPHRENIA RESEARCH, 1999, 35 :S93-S100
[7]   Antipsychotic medication adherence: Is there a difference between typical and atypical agents? [J].
Dolder, CR ;
Lacro, JP ;
Dunn, LB ;
Jeste, DV .
AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (01) :103-108
[8]   Cost-effectiveness of clozapine compared with conventional antipsychotic medication for patients in state hospitals [J].
Essock, SM ;
Frisman, LK ;
Covell, NH ;
Hargreaves, WA .
ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (10) :987-994
[9]  
Finley PR, 1998, PSYCHOPHARMACOL BULL, V34, P75