Alternative polyadenylation of mRNA precursors

被引：783
作者：
Tian, Bin [1 ]
Manley, James L. [2 ]
机构：
[1] Rutgers State Univ, New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, Newark, NJ 07103 USA
[2] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2017年 / 18卷 / 01期
基金：
美国国家卫生研究院;
关键词：
CLEAVAGE FACTOR-I; 3' UNTRANSLATED REGIONS; GENOME-WIDE ANALYSIS; LARGE-SCALE ANALYSIS; POLY(A) TAIL LENGTH; POLYMERASE-II; GENE-EXPRESSION; SR PROTEINS; INTRONIC CLEAVAGE; BINDING PROTEINS;
D O I：
10.1038/nrm.2016.116
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polyrnerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation. In this Review, we discuss the roles of APA in diverse cellular processes, including mRNA metabolism, protein diversification and protein localization, and more generally in gene regulation. We also discuss the molecular mechanisms underlying APA, such as variation in the concentration of core processing factors and RNA-binding proteins, as well as transcription-based regulation.
引用
收藏
页码：18 / 30
页数：13
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