Alternative polyadenylation of mRNA precursors

被引：826

作者：

Tian, Bin ^{[1
]}

Manley, James L. ^{[2
]}

机构：

[1] Rutgers State Univ, New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, Newark, NJ 07103 USA

[2] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2017年 / 18卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CLEAVAGE FACTOR-I; 3' UNTRANSLATED REGIONS; GENOME-WIDE ANALYSIS; LARGE-SCALE ANALYSIS; POLY(A) TAIL LENGTH; POLYMERASE-II; GENE-EXPRESSION; SR PROTEINS; INTRONIC CLEAVAGE; BINDING PROTEINS;

D O I：

10.1038/nrm.2016.116

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polyrnerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation. In this Review, we discuss the roles of APA in diverse cellular processes, including mRNA metabolism, protein diversification and protein localization, and more generally in gene regulation. We also discuss the molecular mechanisms underlying APA, such as variation in the concentration of core processing factors and RNA-binding proteins, as well as transcription-based regulation.

引用

页码：18 / 30

页数：13

共 178 条

[121] An intronic polyadenylation site in human and mouse CstF-77 genes suggests an evolutionarily conserved regulatory mechanism [J].

Pan, ZH ;

Zhang, HB ;

Hague, LK ;

Lee, JY ;

Lutz, CS ;

Tian, B .

GENE, 2006, 366 (02) :325-334

[122] Comparative Analysis of mRNA Isoform Expression in Cardiac Hypertrophy and Development Reveals Multiple Post-Transcriptional Regulatory Modules [J].

Park, Ji Yeon ;

Li, Wencheng ;

Zheng, Dinghai ;

Zhai, Peiyong ;

Zhao, Yun ;

Matsuda, Takahisa ;

Vatner, Stephen F. ;

Sadoshima, Junichi ;

Tian, Bin .

PLOS ONE, 2011, 6 (07)

[123] RNA polymerase II kinetics in polo polyadenylation signal selection [J].

Pinto, Pedro A. B. ;

Henriques, Telmo ;

Freitas, Marta O. ;

Martins, Torcato ;

Domingues, Rita G. ;

Wyrzykowska, Paulina S. ;

Coelho, Paula A. ;

Carmo, Alexandre M. ;

Sunkel, Claudio E. ;

Proudfoot, Nicholas J. ;

Moreira, Alexandra .

EMBO JOURNAL, 2011, 30 (12) :2431-2444

[124] A Polymorphic 3′UTR Element in ATP1B1 Regulates Alternative Polyadenylation and Is Associated with Blood Pressure [J].

Prasad, Megana K. ;

Bhalla, Kavita ;

Pan, Zhen Hua ;

O'Connell, Jeffrey R. ;

Weder, Alan B. ;

Chakravarti, Aravinda ;

Tian, Bin ;

Chang, Yen-Pei C. .

PLOS ONE, 2013, 8 (10)

[125] Ending the message: poly(A) signals then and now [J].

Proudfoot, Nick J. .

GENES & DEVELOPMENT, 2011, 25 (17) :1770-1782

[126] Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS [J].

Prudencio, Mercedes ;

Belzil, Veronique V. ;

Batra, Ranjan ;

Ross, Christian A. ;

Gendron, Tania F. ;

Pregent, Luc J. ;

Murray, Melissa E. ;

Overstreet, Karen K. ;

Piazza-Johnston, Amelia E. ;

Desaro, Pamela ;

Bieniek, Kevin F. ;

DeTure, Michael ;

Lee, Wing C. ;

Biendarra, Sherri M. ;

Davis, Mary D. ;

Baker, Matthew C. ;

Perkerson, Ralph B. ;

van Blitterswijk, Marka ;

Stetler, Caroline T. ;

Rademakers, Rosa ;

Link, Christopher D. ;

Dickson, Dennis W. ;

Boylan, Kevin B. ;

Li, Hu ;

Petrucelli, Leonard .

NATURE NEUROSCIENCE, 2015, 18 (08) :1175-+

[127] Diversity and selectivity in mRNA translation on the endoplasmic reticulum [J].

Reid, David W. ;

Nicchitta, Christopher V. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2015, 16 (04) :221-231

[128] Transcription termination by nuclear RNA polymerases [J].

Richard, Patricia ;

Manley, James L. .

GENES & DEVELOPMENT, 2009, 23 (11) :1247-1269

[129] Transcriptional activators control splicing and 3′-end cleavage levels [J].

Rosonina, E ;

Bakowski, MA ;

McCracken, S ;

Blencowe, BJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (44) :43034-43040

[130] The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3′ mRNA processing factors [J].

Rozenblatt-Rosen, Orit ;

Nagaike, Takashi ;

Francis, Joshua M. ;

Kaneko, Syuzo ;

Glatt, Karen A. ;

Hughes, Christina M. ;

LaFramboise, Thomas ;

Manley, James L. ;

Meyerson, Matthew .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (03) :755-760

← 8 9 10 11 12 13 14 15 16 17 →