Alternative polyadenylation of mRNA precursors

被引：784
作者：
Tian, Bin [1 ]
Manley, James L. [2 ]
机构：
[1] Rutgers State Univ, New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, Newark, NJ 07103 USA
[2] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2017年 / 18卷 / 01期
基金：
美国国家卫生研究院;
关键词：
CLEAVAGE FACTOR-I; 3' UNTRANSLATED REGIONS; GENOME-WIDE ANALYSIS; LARGE-SCALE ANALYSIS; POLY(A) TAIL LENGTH; POLYMERASE-II; GENE-EXPRESSION; SR PROTEINS; INTRONIC CLEAVAGE; BINDING PROTEINS;
D O I：
10.1038/nrm.2016.116
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polyrnerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation. In this Review, we discuss the roles of APA in diverse cellular processes, including mRNA metabolism, protein diversification and protein localization, and more generally in gene regulation. We also discuss the molecular mechanisms underlying APA, such as variation in the concentration of core processing factors and RNA-binding proteins, as well as transcription-based regulation.
引用
收藏
页码：18 / 30
页数：13
相关论文
共 178 条
  • [1] SYNTHESIS OF SECRETED AND MEMBRANE-BOUND IMMUNOGLOBULIN-MU HEAVY-CHAINS IS DIRECTED BY MESSENGER-RNAS THAT DIFFER AT THEIR 3' ENDS
    ALT, FW
    BOTHWELL, ALM
    KNAPP, M
    SIDEN, E
    MATHER, E
    KOSHLAND, M
    BALTIMORE, D
    [J]. CELL, 1980, 20 (02) : 293 - 301
  • [2] ALTERNATIVE RNA PROCESSING IN CALCITONIN GENE-EXPRESSION GENERATES MESSENGER-RNAS ENCODING DIFFERENT POLYPEPTIDE PRODUCTS
    AMARA, SG
    JONAS, V
    ROSENFELD, MG
    ONG, ES
    EVANS, RM
    [J]. NATURE, 1982, 298 (5871) : 240 - 244
  • [3] Distinct role of long 3′ UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons
    An, Juan Ji
    Gharami, Kusumika
    Liao, Guey-Ying
    Woo, Newton H.
    Lau, Anthony G.
    Vanevski, Filip
    Torre, Enrique R.
    Jones, Kevin R.
    Feng, Yue
    Lu, Bai
    Xu, Baoji
    [J]. CELL, 2008, 134 (01) : 175 - 187
  • [4] To localize or not to localize: mRNA fate is in 3′UTR ends
    Andreassi, Catia
    Riccio, Antonella
    [J]. TRENDS IN CELL BIOLOGY, 2009, 19 (09) : 465 - 474
  • [5] Autoregulation at the level of mRNA 3′ end formation of the suppressor of forked gene of Drosophila melanogaster is conserved in Drosophila virilis
    Audibert, A
    Simonelig, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) : 14302 - 14307
  • [6] Crystal structure of murine CsfF-77: Dimeric Association and implications for polyadenylation of mRNA precursors
    Bai, Yun
    Auperin, Thierry C.
    Chou, Chi-Yuan
    Chang, Gu-Gang
    Manley, James L.
    Tong, Liang
    [J]. MOLECULAR CELL, 2007, 25 (06) : 863 - 875
  • [7] UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3′ UTR Transcripts
    Bao, Jianqiang
    Vitting-Seerup, Kristoffer
    Waage, Johannes
    Tang, Chong
    Ge, Ying
    Porse, Bo T.
    Yan, Wei
    [J]. PLOS GENETICS, 2016, 12 (05):
  • [8] Last but not least: Regulated poly(A) tail formation
    Barabino, SML
    Keller, W
    [J]. CELL, 1999, 99 (01) : 9 - 11
  • [9] MicroRNAs: Target Recognition and Regulatory Functions
    Bartel, David P.
    [J]. CELL, 2009, 136 (02) : 215 - 233
  • [10] Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease
    Batra, Ranjan
    Charizanis, Konstantinos
    Manchanda, Mini
    Mohan, Apoorva
    Li, Moyi
    Finn, Dustin J.
    Goodwin, Marianne
    Zhang, Chaolin
    Sobczak, Krzysztof
    Thornton, Charles A.
    Swanson, Maurice S.
    [J]. MOLECULAR CELL, 2014, 56 (02) : 311 - 322
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