Epigenetic memory: the Lamarckian brain

被引：74

作者：

Fischer, Andre ^{[1
,2
]}

机构：

[1] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

[2] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

来源：

EMBO JOURNAL | 2014年 / 33卷 / 09期

关键词：

Alzheimer's disease; epigenetics; histone-acetylation; memory; neurodegeneration; non-coding RNA; LONG-TERM-MEMORY; RUBINSTEIN-TAYBI-SYNDROME; CREB-BINDING-PROTEIN; HISTONE DEACETYLASE INHIBITOR; ALZHEIMERS-DISEASE BRAIN; GENOME-WIDE ANALYSIS; RNA-SEQ ANALYSIS; DNA METHYLATION; MOUSE MODEL; SYNAPTIC PLASTICITY;

D O I：

10.1002/embj.201387637

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent data support the view that epigenetic processes play a role in memory consolidation and help to transmit acquired memories even across generations in a Lamarckian manner. Drugs that target the epigenetic machinery were found to enhance memory function in rodents and ameliorate disease phenotypes in models for brain diseases such as Alzheimer's disease, Chorea Huntington, Depression or Schizophrenia. In this review, I will give an overview on the current knowledge of epigenetic processes in memory function and brain disease with a focus on Morbus Alzheimer as the most common neurodegenerative disease. I will address the question whether an epigenetic therapy could indeed be a suitable therapeutic avenue to treat brain diseases and discuss the necessary steps that should help to take neuroepigenetic research to the next level.

引用

页码：945 / 967

页数：23

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