Acquired Bernard-Soulier syndrome and hypodysfibrinogenaemia because of multiple myeloma

被引：1

作者：

Sehgal, Tushar ^{[1
,2
]}

Altohami, Mohammed ^{[1
]}

Lafferty, Nicholas ^{[1
]}

Desborough, Michael ^{[3
]}

Boyce, Sara ^{[1
]}

Kazmi, Rashid ^{[1
]}

Jenner, Matthew ^{[1
]}

机构：

[1] Univ Hosp Southampton NHS Fdn Trust, Dept Clin Hematol, London, England

[2] All India Inst Med Sci, Dept Lab Med Hematol, New Delhi, India

[3] Oxford Univ Hosp, Dept Clin Hematol, Oxford, England

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 2022年 / 33卷 / 02期

关键词：

Bernard-Soulier syndrome; bleeding; hypodysfibrinogenaemia; myeloma; DIAGNOSIS;

D O I：

10.1097/MBC.0000000000001104

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a case of a patient with multiple myeloma with initial presentation simulating a bleeding disorder. Detailed coagulation work-up showed hypodysfibrinogenaemia along with a platelet function defect consistent with acquired Bernard -Soulier syndrome (BSS). Multiple plasma exchanges led to significant improvement in his bleeding symptoms. To the best of our knowledge, this is the first described case of simultaneous presentation of hypodysfibrinogenaemia and BSS secondary to multiple myeloma. Copyright (C) 2021 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：130 / 133

页数：4

共 15 条

[11] HEMOSTATIC ABNORMALITIES ASSOCIATED WITH MONOCLONAL GAMMOPATHIES [J].

ROBERT, F ;

MIGNUCCI, M ;

MCCURDY, SA ;

MALDONADO, N ;

LEE, JY .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1993, 306 (06) :359-366

[12] ACQUIRED BERNARD-SOULIER SYNDROME - EVIDENCE FOR THE ROLE OF A 210,000-MOLECULAR WEIGHT PROTEIN IN THE INTERACTION OF PLATELETS WITH VON WILLEBRAND FACTOR [J].

STRICKER, RB ;

WONG, D ;

SAKS, SR ;

CORASH, L ;

SHUMAN, MA .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (03) :1274-1278

[13] Beyond the CRAB Symptoms: A Study of Presenting Clinical Manifestations of Multiple Myeloma [J].

Talamo, Giampaolo ;

Farooq, Umar ;

Zangari, Maurizio ;

Liao, Jason ;

Dolloff, Nathan G. ;

Loughran, Thomas R., Jr. ;

Epner, Elliot .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2010, 10 (06) :464-468

[14] The prolonged activated partial thromboplastin time at diagnosis indicates less favorable prognosis in IgA myeloma [J].

Teng, Hao-Wei ;

Chen, Po-Min ;

Yang, Ya-Hsu ;

Gau, Jyh-Pyng .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2007, 37 (08) :609-614

[15] Diagnosis and treatment of acquired von Willebrand syndrome [J].

Tiede, Andreas .

THROMBOSIS RESEARCH, 2012, 130 :S2-S6

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