Telomeres and human somatic fitness

被引：93

作者：

Aviv, Abraham ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Ctr Human Dev & Aging, New Jersey Med Sch, Newark, NJ 07103 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2006年 / 61卷 / 08期

关键词：

D O I：

10.1093/gerona/61.8.871

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Mean leukocyte telomere length may be an indicator of biological age, and as such it appears to provide information over and above chronological age of the risk for developing diseases of aging in humans. Here I propose that the mean leukocyte telomere length is an index of "somatic fitness," a concept that breaks down the artificial boundary between aging and diseases of aging. I also propose that, in exceptionally old humans, ultrashort leukocyte telomeres might be a determinant of life span.

引用

页码：871 / 873

页数：3

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