Carbapenem-Resistant Enterobacteriaceae in Children, United States, 1999-2012

被引：85

作者：

Logan, Latania K. ^{[1
,2
]}

Renschler, John P. ^{[3
]}

Gandra, Sumanth ^{[3
]}

Weinstein, Robert A. ^{[1
,2
]}

Laxminarayan, Ramanan ^{[3
,4
,5
]}

机构：

[1] Rush Univ, Med Ctr, Chicago, IL 60612 USA

[2] John H Stroger Jr Hosp Cook Cty, Chicago, IL USA

[3] Ctr Dis Dynam Econ & Policy, Washington, DC USA

[4] Publ Hlth Fdn India, New Delhi, India

[5] Princeton Univ, Princeton, NJ 08544 USA

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 11期

基金：

美国国家卫生研究院;

关键词：

LACTAMASE-PRODUCING ENTEROBACTERIACEAE; INTENSIVE-CARE-UNIT; KLEBSIELLA-PNEUMONIAE; K; PNEUMONIAE; RISK-FACTORS; INFECTION; HOSPITALS; EPIDEMIOLOGY; CARRIAGE; CLOACAE;

D O I：

10.3201/eid2111.150548

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prevalence of carbapenem-resistant Enterobacteriaceae (ORE) infections is increasing in the United States. However, few studies have addressed their epidemiology in children. To phenotypically identify CRE isolates cultured from patients 1-17 years of age, we used antimicrobial susceptibilities of Enterobacteriaceae reported to 300 laboratories participating in The Surveillance Network USA database during January 1999-July 2012. Of 316,253 isolates analyzed, 266 (0.08%) were identified as ORE. ORE infection rate increases were highest for Enterobacter species, blood culture isolates, and isolates from intensive care units, increasing from 0.0% in 1999-2000 to 5.2%, 4.5%, and 3.2%, respectively, in 2011-2012. ORE occurrence in children is increasing but remains low and is less common than that for extended-spectrum beta-lactamase producing Enterobacteriaceae. The molecular characterization of ORE isolates from children and clinical epidemiology of infection are essential for development of effective prevention strategies.

引用

页码：2014 / 2021

页数：8

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