Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease

被引：33

作者：

Arai, Taeang ^{[1
]}

Atsukawa, Masanori ^{[2
]}

Tsubota, Akihito ^{[3
]}

Koeda, Mai ^{[1
]}

Yoshida, Yuji ^{[1
]}

Okubo, Tomomi ^{[1
]}

Nakagawa, Ai ^{[2
]}

Itokawa, Norio ^{[1
]}

Kondo, Chisa ^{[2
]}

Nakatsuka, Katsuhisa ^{[2
]}

Masu, Takushi ^{[2
]}

Kato, Keizo ^{[4
]}

Shimada, Noritomo ^{[5
]}

Hatori, Tsutomu ^{[6
]}

Emoto, Naoya ^{[7
]}

Kage, Masayoshi ^{[8
]}

Iwakiri, Katsuhiko ^{[2
]}

机构：

[1] Chiba Hokusoh Hosp, Nippon Med Sch, Dept Internal Med, Div Gastroenterol, Chiba, Japan

[2] Nippon Med Sch, Dept Internal Med, Div Gastroenterol & Hepatol, Tokyo, Japan

[3] Jikei Univ, Sch Med, Res Ctr Med Sci, Core Res Facil Basic Sci, Tokyo, Japan

[4] Shinmatsudo Cent Gen Hosp, Dept Internal Med, Dept Gastroenterol & Hepatol, Matsudo, Chiba, Japan

[5] Otakanomori Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Kashiwa, Chiba, Japan

[6] Chiba Hokusoh Hosp, Nippon Med Sch, Div Pathol, Chiba, Japan

[7] Chiba Hokusoh Hosp, Nippon Med Sch, Dept Internal Med, Div Endocrinol, Chiba, Japan

[8] Kurume Univ, Res Ctr Innovat Canc Therapy, Mol Targeting Therapeut Div, Fukuoka, Fukuoka, Japan

来源：

DIGESTIVE AND LIVER DISEASE | 2019年 / 51卷 / 07期

基金：

日本学术振兴会;

关键词：

Histopathological liver severity; NAFLD; Vitamin D receptor gene; 25-HYDROXYVITAMIN D LEVEL; D-RECEPTOR POLYMORPHISMS; INSULIN-RESISTANCE; CLINICAL-PRACTICE; NAFLD; SEVERITY; COMMON; DETERMINANTS; EXPRESSION; GUIDELINES;

D O I：

10.1016/j.dld.2018.12.022

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Vitamin D has promising anti-proliferative and anti-fibrotic properties, but its clinical utility in nonalcoholic fatty liver disease (NAFLD) is unclear. Aims: This study aimed to clarify the association between vitamin D levels, single nucleotide polymorphisms (SNPs) in vitamin D-related genes, and the histopathological severity of disease in patients with biopsy-proven NAFLD. Methods: SNPs in CYP2R1, DHCR7, vitamin D binding protein (GC), CYP27B1, and vitamin D receptor (VDR) were determined for 229 consecutive patients with biopsy-proven NAFLD. Results: In this study, vitamin D deficiency defined as 25-hydroxyvitamin-D3 levels of <= 20 ng/mL was found in 151 patients (65.9%). Multivariate analysis revealed that cold season, advanced fibrosis, and CYP2R1 rs1993116 genotype non-AA were independent factors significantly associated with vitamin D deficiency. Old age (p = 5.05 x 10(-8)), high body mass index (p = 2.13 x 10(-2)), low total-cholesterol (p = 1.46 x 10(-4)), low serum vitamin D level (p = 7.34 x 10(-3)), and VDR rs1544410 genotype CC (p = 9.15 x 10(-3)) were independent factors associated with advanced liver fibrosis. Conclusion: Serum 25-hydroxyvitamin-D3 levels and the VDR gene SNP were significantly and independently associated with the severity of liver fibrosis in patients with biopsy-proven NAFLD. (C) 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：1036 / 1042

页数：7

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