In Vivo Antibacterial Activity of MRX-I, a New Oxazolidinone

被引：55

作者：

Li, Cong-Ran ^{[1
,2
]}

Zhai, Qian-Qian ^{[1
,2
]}

Wang, Xiu-Kun ^{[1
,2
]}

Hu, Xin-Xin ^{[1
,2
]}

Li, Guo-Qing ^{[1
,2
]}

Zhang, Wei-Xin ^{[1
,2
]}

Pang, Jing ^{[1
,2
]}

Lu, Xi ^{[1
,2
]}

Yuan, Hong ^{[3
]}

Gordeev, Mikhail Fedorovich ^{[3
]}

Chen, Le-Tian ^{[4
]}

Yang, Xin-Yi ^{[1
,2
]}

You, Xue-Fu ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100730, Peoples R China

[2] Peking Union Med Coll, Beijing 100021, Peoples R China

[3] MicuRx Pharmaceut Inc, Hayward, CA USA

[4] Capital Med Univ, Beijing Friendship Hosp, Beijing, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 04期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1128/AAC.01526-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

MRX-I is a potent oxazolidinone antibiotic against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), penicillin-intermediate S. pneumoniae (PISP), and vancomycin-resistant enterococci (VRE). In this study, the in vivo efficacy of orally administered MRX-I was evaluated using linezolid as a comparator. MRX-I showed the same or better efficacy than linezolid in both systemic and local infection models against the tested strains.

引用

页码：2418 / 2421

页数：4

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