Total synthesis of (-)-clavosolide A

被引:20
作者
Chakraborty, Tushar Kanti [1 ]
Reddy, Vakiti Ramkrishna [1 ]
Chattopadhyay, Anut Kumar [1 ]
机构
[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India
关键词
clavosolides; clavosolide A; epoxide opening; 2-methyl-1,3-diol; diolide;
D O I
10.1016/j.tetlet.2006.08.055
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The total synthesis of (-)-clavosolide A is achieved employing a radical-mediated route to build the substituted tetrahydropyran unit, a Yamaguchi reaction to construct the diolide aglycon and the Schmidt method for the final glycosidation step. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:7435 / 7438
页数:4
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