γ-secretase-mediated proteolysis in cell-surface-receptor signalling

被引：336
作者：
Fortini, ME [1 ]
机构：
[1] NCI, Div Basic Sci, Frederick, MD 21702 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm910
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Many cell-surface receptors transmit signals to the nucleus through complex protein cascades. By contrast, the Notch signalling pathway uses a relatively direct mechanism, in which the intracellular domain of the receptor is liberated by intramembrane cleavage and translocates to the nucleus. This critical cleavage is mediated by the gamma-secretase complex, and new findings reveal that this mechanism is used by various receptors, although many questions remain about the biochemical details.
引用
收藏
页码：673 / 684
页数：12
相关论文
共 146 条
  • [1] Presenilins: molecular switches between proteolysis and signal transduction
    Annaert, W
    De Strooper, B
    [J]. TRENDS IN NEUROSCIENCES, 1999, 22 (10) : 439 - 443
  • [2] Endogenous β-amyloid production in presenilin-deficient embryonic mouse fibroblasts
    Armogida, M
    Petit, A
    Vincent, B
    Scarzello, S
    da Costa, CA
    Checler, F
    [J]. NATURE CELL BIOLOGY, 2001, 3 (11) : 1030 - 1033
  • [3] Notch signaling: Cell fate control and signal integration in development
    Artavanis-Tsakonas, S
    Rand, MD
    Lake, RJ
    [J]. SCIENCE, 1999, 284 (5415) : 770 - 776
  • [4] NOTCH SIGNALING
    ARTAVANISTSAKONAS, S
    MATSUNO, K
    FORTINI, ME
    [J]. SCIENCE, 1995, 268 (5208) : 225 - 232
  • [5] Identification and characterization of presenilin-independent Notch signaling
    Berechid, BE
    Kitzmann, M
    Foltz, DR
    Roach, AH
    Seiffert, D
    Thompson, LA
    Olson, RE
    Bernstein, A
    Donoviel, DB
    Nye, JS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (10) : 8154 - 8165
  • [6] Lack of requirement for Presenilin1 in Notch1 signaling
    Berechid, BE
    Thinakaran, G
    Wong, PC
    Sisodia, SS
    Nye, JS
    [J]. CURRENT BIOLOGY, 1999, 9 (24) : 1493 - 1496
  • [7] Aspartate mutations in presenilin and γ-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling
    Berezovska, O
    Jack, C
    McLean, P
    Aster, JC
    Hicks, C
    Xia, WM
    Wolfe, MS
    Kimberly, WT
    Weinmaster, G
    Selkoe, DJ
    Hyman, BT
    [J]. JOURNAL OF NEUROCHEMISTRY, 2000, 75 (02) : 583 - 593
  • [8] Intracellular cleavage of notch leads to a heterodimeric receptor on the plasma membrane
    Blaumueller, CM
    Qi, HL
    Zagouras, P
    ArtavanisTsakonas, S
    [J]. CELL, 1997, 90 (02) : 281 - 291
  • [9] Blaumueller CM, 1997, PERSPECT DEV NEUROBI, V4, P325
  • [10] A novel proteolytic cleavage involved in Notch signaling:: The role of the disintegrin-metalloprotease TACE
    Brou, C
    Logeat, F
    Gupta, N
    Bessia, C
    LeBail, O
    Doedens, JR
    Cumano, A
    Roux, P
    Black, RA
    Israël, A
    [J]. MOLECULAR CELL, 2000, 5 (02) : 207 - 216
12345678910