Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature

被引:153
作者
Nguyen, Andrew [1 ]
Guo, James [1 ]
Banyard, Derek A. [1 ]
Fadavi, Darya [1 ]
Toranto, Jason D. [1 ]
Wirth, Garrett A. [1 ]
Paydar, Keyianoosh Z. [1 ]
Evans, Gregory R. D. [2 ]
Widgerow, Alan D. [1 ]
机构
[1] Univ Calif Irvine, Dept Plast Surg, Ctr Tissue Engn, Irvine, CA USA
[2] Univ Calif Irvine, Dept Plast Surg, Irvine, CA USA
关键词
Stromal vascular fraction; Adipose derived stem cells; Progenitor cells; Preadipocytes; Stem cell regeneration; CELL-ASSISTED LIPOTRANSFER; GRAFTING BASIC RESEARCH; ADIPOSE-DERIVED CELLS; BREAST-CANCER CELLS; STEM-CELLS; FAT GRAFTS; SUPPORTIVE USE; DIABETIC FOOT; IN-VITRO; TISSUE;
D O I
10.1016/j.bjps.2015.10.015
中图分类号
R61 [外科手术学];
学科分类号
摘要
Stromal Vascular Fraction (SVF) is a heterogeneous collection of cells contained within adipose tissue that is traditionally isolated using enzymes such as collagenase. With the removal of adipose cells, connective tissue and blood from lipoaspirate, comes the SVF, a mix including mesenchymal stem cells, endothelial precursor cells, T regulatory cells, macrophages, smooth muscle cells, pericytes and preadipocytes. In part 1 of our 2-part series, we review the literature with regards to the intensifying interest that has shifted toward this mixture of cells, particularly due to its component synergy and translational potential. Trials assessing the regenerative potential of cultured Adipose Derived Stem Cells (ADSCs) and SVF demonstrate that SVF is comparably effective in treating conditions ranging from radiation injuries, burn wounds and diabetes, amongst others. Aside from their use in chronic conditions, SVF enrichment of fat grafts has proven a major advance in maintaining fat graft volume and viability. Many SVF studies are currently in preclinical phases or are moving to human trials. Overall, regenerative cell therapy based on SVF is at an early investigative stage but its potential for clinical application is enormous. (C) 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:170 / 179
页数:10
相关论文
共 59 条
  • [1] Cell-assisted lipotransfer for cosmetic breast augmentation: Supportive use of adipose-derived stem/stromal cells
    Altman, Andrew M.
    Alt, Eckhard U.
    [J]. AESTHETIC PLASTIC SURGERY, 2008, 32 (01) : 56 - 57
  • [2] Epicardial delivery of collagen patches with adipose-derived stem cells in rat and minipig models of chronic myocardial infarction
    Arana, Miriam
    Gavira, Juan J.
    Pena, Estefania
    Gonzalez, Arantxa
    Abizanda, Gloria
    Cilla, Myriam
    Perez, Marta M.
    Albiasu, Edurne
    Aguado, Natalia
    Casado, Mayte
    Lopez, Begona
    Gonzalez, Susana
    Soriano, Mario
    Moreno, Cristina
    Merino, Juana
    Garcia-Verdugo, Jose M.
    Diez, Javier
    Doblare, Manuel
    Pelacho, Beatriz
    Prosper, Felipe
    [J]. BIOMATERIALS, 2014, 35 (01) : 143 - 151
  • [3] Stromal vascular fraction improves deep partial thickness burn wound healing
    Atalay, Sibel
    Coruh, Atilla
    Deniz, Kemal
    [J]. BURNS, 2014, 40 (07) : 1375 - 1383
  • [4] Implications for human adipose-derived stem cells in plastic surgery
    Banyard, Derek A.
    Salibian, Ara A.
    Widgerow, Alan D.
    Evans, Gregory R. D.
    [J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2015, 19 (01) : 21 - 30
  • [5] Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)
    Bourin, Philippe
    Bunnell, Bruce A.
    Casteilla, Louis
    Dominici, Massimo
    Katz, Adam J.
    March, Keith L.
    Redl, Heinz
    Rubin, J. Peter
    Yoshimura, Kotaro
    Gimble, Jeffrey M.
    [J]. CYTOTHERAPY, 2013, 15 (06) : 641 - 648
  • [6] Antiaging Treatment of the Facial Skin by Fat Graft and Adipose-Derived Stem Cells
    Charles-de-Sa, Luiz
    Gontijo-de-Amorim, Natale Ferreira
    Takiya, Christina Maeda
    Borojevic, Radovan
    Benati, Donatella
    Bernardi, Paolo
    Sbarbati, Andrea
    Rigotti, Gino
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2015, 135 (04) : 999 - 1009
  • [7] Adipose-Derived Stromal Vascular Fraction Differentially Expands Breast Progenitors in Tissue Adjacent to Tumors Compared to Healthy Breast Tissue
    Chatterjee, Sumanta
    Laliberte, Mike
    Blelloch, Sarah
    Ratanshi, Imran
    Safneck, Janice
    Buchel, Ed
    Raouf, Afshin
    [J]. PLASTIC AND RECONSTRUCTIVE SURGERY, 2015, 136 (04) : 414E - 425E
  • [8] Isolation of Human Adipose-Derived Stromal Cells Using Laser-Assisted Liposuction and Their Therapeutic Potential in Regenerative Medicine
    Chung, Michael T.
    Zimmermann, Andrew S.
    Paik, Kevin J.
    Morrison, Shane D.
    Hyun, Jeong S.
    Lo, David D.
    McArdle, Adrian
    Montoro, Daniel T.
    Walmsley, Graham G.
    Senarath-Yapa, Kshemendra
    Sorkin, Michael
    Rennert, Robert
    Chen, Hsin-Han
    Chung, Andrew S.
    Vistnes, Dean
    Gurtner, Geoffrey C.
    Longaker, Michael T.
    Wan, Derrick C.
    [J]. STEM CELLS TRANSLATIONAL MEDICINE, 2013, 2 (10) : 808 - 817
  • [9] Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
    Constantinescu, Cris S.
    Farooqi, Nasr
    O'Brien, Kate
    Gran, Bruno
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2011, 164 (04) : 1079 - 1106
  • [10] Role of mesenchymal stem cell therapy in Crohn's disease
    Dalal, Jignesh
    Gandy, Kimberly
    Domen, Jos
    [J]. PEDIATRIC RESEARCH, 2012, 71 (04) : 445 - 451