The relationship between aberrant methylation and survival in non-small-cell lung cancers

被引：60
作者：
Toyooka, S
Suzuki, M
Maruyama, R
Toyooka, KO
Tsukuda, K
Fukuyama, Y
Iizasa, T
Aoe, M
Date, H
Fujisawa, T
Shimizu, N
Gazdar, AF
机构：
[1] Univ Texas, SW Med Ctr, Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
[2] Okayama Univ, Sch Med, Dept Canc & Thorac Surg, Okayama 700, Japan
[3] Kyushu Univ, Fac Med, Dept Surg 2, Fukuoka 812, Japan
[4] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX USA
来源：
BRITISH JOURNAL OF CANCER | 2004年 / 91卷 / 04期
关键词：
methylation; p16(INK4a); non-small-cell lung cancer; adenocarcinoma of lung;
D O I：
10.1038/sj.bjc.6602013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARbeta and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.
引用
收藏
页码：771 / 774
页数：4
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