Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites

被引：15

作者：

Odovic, Jadranka ^{[2
]}

Aleksic, Mirjana ^{[2
]}

Stojimirovic, Biljana ^{[3
]}

Milojkovic-Opsenica, Dusanka ^{[1
]}

Tesic, Zivoslav ^{[1
]}

机构：

[1] Univ Belgrade, Fac Chem, Belgrade 11158, Serbia

[2] Univ Belgrade, Fac Pharm, Belgrade 11001, Serbia

[3] Univ Belgrade, Sch Med, Belgrade 11000, Serbia

来源：

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2009年 / 74卷 / 06期

关键词：

ACE inhibitors; normal-phase thin-layer chromatography; hydrophobicity; PERFORMANCE LIQUID-CHROMATOGRAPHY; PARTITION-COEFFICIENTS; RETENTION BEHAVIOR; ACTIVE METABOLITE; LIPOPHILICITY; SEPARATION;

D O I：

10.2298/JSC0906677O

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the R-M values and the composition 0 of employed mobile phase was obtained. The hydrophobicity parameters R-M(0) and C-0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography.

引用

页码：677 / 688

页数：12

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