Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: Pathogenesis and histological characteristics

被引:19
作者
Aishima, Shinichi [1 ]
Tanaka, Yuki [2 ]
Kubo, Yuichiro [2 ]
Shirabe, Ken [3 ]
Maehara, Yoshihiko [3 ]
Oda, Yoshinao [2 ]
机构
[1] Saga Univ, Fac Med, Dept Pathol & Microbiol, Saga 8498501, Japan
[2] Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Fukuoka 812, Japan
[3] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka 812, Japan
关键词
bile duct adenoma; cirrhosis; hamartoma; BILIARY INTRAEPITHELIAL NEOPLASIA; B-VIRUS-INFECTION; INTRAHEPATIC CHOLANGIOCARCINOMA; RISK-FACTORS; TUMOR PROGRESSION; VIRAL-HEPATITIS; LIVER; CARCINOMA; EXPRESSION; HAMARTOMA;
D O I
10.1111/pin.12209
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Morphologic features and neoplastic potentials of bile duct adenoma (BDA) and von Meyenburg complex (VMC)-like duct arising in chronic liver disease were unknown. Thirty-five BDAs and 12 VMC-like duct lesions were observed in 39 cases with chronic liver disease. BDAs were divided into the EMA-cytoplasmic type (n = 14) and EMA-luminal type (n = 21). EMA-cytoplasmic BDA composed of a proliferation of cuboidal to low-columnar cells forming an open lumen with NCAM(+)/MUC6(-), resembling an interlobular bile duct. EMA-luminal BDA showed uniform cuboidal cells with narrow lumen, and NCAM(++)/MUC6(++), resembling a ductular reaction. VMC-like duct showed positive MUC1 expression and negative MUC6. The expression of S100P, glucose transporter-1 (GLUT-1) and insulin-like growth factor II mRNA-binding protein 3 (IMP-3) were not detected in three lesions. p16 expression was higher than those of the ductular reaction, and the Ki67 and p53 indexes were very low (<1.0%). Large-sized EMA-luminal BDA shows sclerotic stroma. We classified small nodular lesions of ductal or ductular cells in chronic hepatitis and cirrhosis into the following groups: BDA, interlobular bile duct type; BDA, ductular/peribiliary gland type; and VMC-like duct. They may be reactive proliferation rather than neoplastic lesions.
引用
收藏
页码:551 / 559
页数:9
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