Antimalarial Natural Products of Marine and Freshwater Origin

被引：47

作者：

Gademann, Karl ^{[1
]}

Kobylinska, Joanna ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol, Chem Synth Lab, SB ISIC LSYNC, CH-1015 Lausanne, Switzerland

来源：

CHEMICAL RECORD | 2009年 / 9卷 / 03期

关键词：

antimalaria; bioactivity; cytotoxic; natural products; marine sponges; CYANOBACTERIAL ALKALOID NOSTOCARBOLINE; PSEUDOMONAS SP F92S91; PLASMODIUM-FALCIPARUM; MICROCYSTIS-AERUGINOSA; ABSOLUTE STEREOCHEMISTRY; CHEMICAL TRANSFORMATION; MANZAMINE ALKALOIDS; PSEUDOPYRONINE-B; SPONGE; MALARIA;

D O I：

10.1002/tcr.200900001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review highlights recently discovered antimalarial natural products from marine and freshwater sources described in the literature from 2006 to 2008. The structures as well as bioactivities of compounds against the malaria parasites such as Plasmodium falciparum are discussed, including, for example, agelasine, xestoquinone, alisiaquinone, crambescidin, venturamide, dragomabin, gragonamide, viridamide, salinosporamide, chaetoxanthone, nodulisporacid, tumonoic acid, girolline, oroidin, nostocarboline, acrucyclamide, and microcylamide 7806 and its revised structure. Synthetic derivatives of natural products are presented including plakortin, isoaaptamine, curcuphenol, pseudopyronine, manzamine, and nostocarboline. Consequences of these discoveries for the development of novel natural product agents against malaria are discussed. (C) 2009 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 9: 187-198; 2009: Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/tcr.200900001

引用

页码：187 / 198

页数：12

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