Human Peripheral Blood Dendritic Cell and T Cell Activation by Codium fragile Polysaccharide

被引：16

作者：

Zhang, Wei ^{[1
]}

Hwang, Juyoung ^{[1
,2
,3
]}

Park, Hae-Bin ^{[1
,2
,3
]}

Lim, Seong-Min ^{[2
,3
]}

Go, Seulgi ^{[2
,3
]}

Kim, Jihoe ^{[2
,3
]}

Choi, Inho ^{[2
,3
]}

You, Sangguan ^{[4
]}

Jin, Jun-O ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China

[2] Yeungnam Univ, Dept Med Biotechnol, Gyongsan 38541, South Korea

[3] Yeungnam Univ, Res Inst Cell Culture, Gyongsan 38541, South Korea

[4] Gangneung Wonju Natl Univ, Dept Marine Food Sci & Technol, 120 Gangneung Daehangno, Kangnung 210702, Gangwon, South Korea

来源：

MARINE DRUGS | 2020年 / 18卷 / 11期

基金：

新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

Codium fragile polysaccharide; BDCA1; PBDC; BDCA3; helper T cell; cytotoxic T lymphocyte; SULFATED POLYSACCHARIDES; PURIFICATION; FUCOIDAN; EFFICACY; RECEPTOR;

D O I：

10.3390/md18110535

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Natural polysaccharides exhibit an immunostimulatory effect with low toxicity in humans and animals. It has shown that polysaccharide extracted from Codium fragile (CFP) induces anti-cancer immunity by dendritic cell (DC) activation, while the effect of CFP has not examined in the human immune cells. In this study, we found that CFP promoted the upregulation of CD80, CD83 and CD86 and major histocompatibility complex (MHC) class I and II in human monocyte-derived dendritic cells (MDDCs). In addition, CFP induced the production of proinflammatory cytokines in MDDCs. Moreover, CFP directly induced the activation of Blood Dendritic Cell Antigen (BDCA)1(+) and BDCA3(+) subsets of human peripheral blood DCs (PBDCs). The CFP-stimulated BDCA1(+) PBDCs further promoted activation and proliferation of syngeneic CD4 T cells. The CFP-activated BDCA3(+) PBDCs activated syngeneic CD8 T cells, which produced cytotoxic mediators, namely, cytotoxic T lymphocytes. These results suggest that CFP may be a candidate molecule for enhancing immune activation in humans.

引用

页数：13

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