Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate

被引：10

作者：

Balzarini, J. ^{[1
]}

Ruchko, E. A. ^{[2
]}

Zakharova, E. K. ^{[3
]}

Kameneva, I. Yu. ^{[3
]}

Nawrozkij, M. B. ^{[3
]}

机构：

[1] Rega Inst Med Res, B-3000 Leuven, Belgium

[2] Joint Stock Co Pharm Synth, Moscow 111024, Russia

[3] Volgograd State Univ, Volgograd 400005, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2014年 / 50卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

umifenovir; conformationally restricted analogs; antiviral activity; RESPIRATORY VIRUSES; ANTIVIRAL ACTIVITY; ARBIDOL; AGENTS;

D O I：

10.1007/s10593-014-1499-y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study.

引用

页码：489 / 495

页数：7

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