Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1H-Indole-3-Carboxylate

被引：10
|
作者：
Balzarini, J. [1 ]
Ruchko, E. A. [2 ]
Zakharova, E. K. [3 ]
Kameneva, I. Yu. [3 ]
Nawrozkij, M. B. [3 ]
机构：
[1] Rega Inst Med Res, B-3000 Leuven, Belgium
[2] Joint Stock Co Pharm Synth, Moscow 111024, Russia
[3] Volgograd State Univ, Volgograd 400005, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2014年 / 50卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
umifenovir; conformationally restricted analogs; antiviral activity; RESPIRATORY VIRUSES; ANTIVIRAL ACTIVITY; ARBIDOL; AGENTS;
D O I：
10.1007/s10593-014-1499-y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study.
引用
收藏
页码：489 / 495
页数：7
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