TIN2, a new regulator of telomere length in human cells

被引：418

作者：

Kim, SH ^{[1
]}

Kaminker, P ^{[1
]}

Campisi, J ^{[1
]}

机构：

[1] Lawrence Berkeley Natl Lab, Dept Cell & Mol Biol, Berkeley, CA 94720 USA

来源：

NATURE GENETICS | 1999年 / 23卷 / 04期

关键词：

D O I：

10.1038/70508

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Telomeres are DNA-protein structures that cap linear chromosomes and are essential for maintaining genomic stability and cell phenotype. We identified a novel human telomere-associated protein, TIN2, by interaction cloning using the telomeric DNA-binding-protein TRF1 as a bait. TIN2 interacted with TRF1 in vitro and in cells, and colocalized with TRF1 in nuclei and metaphase chromosomes. A mutant TIN2 that lacks amino-terminal sequences effects elongated human telomeres in a telomerase-dependent manner. Our findings suggest that TRF1 is insufficient for control of telomere length in human cells, and that TIN2 is an essential mediator of TRF1 function.

引用

页码：405 / 412

页数：8

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