Clinical significance of isolated del(7p) in myeloid neoplasms

被引：6

作者：

Gur, Hatice Deniz ^{[1
]}

Wang, Sa A. ^{[1
]}

Tang, Zhenya ^{[1
]}

Hu, Shimin ^{[1
]}

Li, Shaoying ^{[1
]}

Medeiros, Jeffrey ^{[1
]}

Tang, Guilin ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, 151 Holcombe Blvd, Houston, TX 77030 USA

来源：

LEUKEMIA RESEARCH | 2017年 / 55卷

关键词：

Del(7p); Myeloid neoplasms; Disease progression; Refractory to therapy; PRIMARY MYELODYSPLASTIC SYNDROMES; ACUTE LYMPHOBLASTIC-LEUKEMIA; CYTOGENETIC ABNORMALITIES; SCORING SYSTEM; IKZF1; DELETION; MONOSOMY-7; THERAPIES; RECURRENT; RUNX1;

D O I：

10.1016/j.leukres.2017.01.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sole del(7p) is a rare finding in myeloid neoplasms and its clinical significance is largely unknown. Here we report 10 patients with isolated del(7p), 4 had acute myeloid leukemia (AML), 2 myelodysplastic syndromes (MDS), 1 chronic myelomonocytic leukemia (CMML), 1 primary myelofibrosis (PMF), and 2 AML in remission. Seven patients had large and 3 had small del(7p) clone. For patients with AML, 3 acquired del(7p) either at disease relapse or disease progression, then became refractory to therapy and died shortly thereafter (median 5 months). Detection of del(7p) in patients with MDS, CMML, or PMF appeared to predict poorer prognosis as all 4 patients experienced disease progression or transformation to AML after 5-24 months. In the remaining 3 patients (1 AML and 2 AML in remission), del(7p) was only detected in 10% to 30% of metaphases and was a transient finding that did not appear to have any clinical impact. We conclude that detection of del(7p) in myeloid neoplasms, when presents as a major clone, often poses a high risk for disease progression and refractoriness to therapy; whereas when del( 7p) presents as a small clone, it may not carry any clinical significance. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：18 / 22

页数：5

共 18 条

[1] Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study [J].

Boer, J. M. ;

van der Veer, A. ;

Rizopoulos, D. ;

Fiocco, M. ;

Sonneveld, E. ;

de Groot-Kruseman, H. A. ;

Kuiper, R. P. ;

Hoogerbrugge, P. ;

Horstmann, M. ;

Zaliova, M. ;

Palmi, C. ;

Trka, J. ;

Fronkova, E. ;

Emerenciano, M. ;

Pombo-de-Oliveira, M. do Socorro ;

Mlynarski, W. ;

Szczepanski, T. ;

Nebral, K. ;

Attarbaschi, A. ;

Venn, N. ;

Sutton, Rosemary ;

Schwab, C. J. ;

Enshaei, A. ;

Vora, A. ;

Stanulla, M. ;

Schrappe, M. ;

Cazzaniga, G. ;

Conter, V. ;

Zimmermann, M. ;

Moorman, A. V. ;

Pieters, R. ;

den Boer, M. L. .

LEUKEMIA, 2016, 30 (01) :32-38

[2] Better prognosis for patients with del(7q) than for patients with monosomy 7 in myelodysplastic syndrome [J].

Cordoba, Iris ;

Gonzalez-Porras, Jose R. ;

Nomdedeu, Benet ;

Luno, Elisa ;

de Paz, Raquel ;

Such, Esperanza ;

Tormo, Mar ;

Vallespi, Teresa ;

Collado, Rosa ;

Xicoy, Blanca ;

Andreu, Rafael ;

Munoz, Juan A. ;

Sole, Francesc ;

Cervera, Jose ;

del Canizo, Consuelo .

CANCER, 2012, 118 (01) :127-133

[3] Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia [J].

de Rooji, Jasmiji D. E. ;

Beuling, Eva ;

van den Heuvel-Eibrink, Marry M. ;

Obulkasim, Askar ;

Baruchel, Andre ;

Trka, Jan ;

Reinhardt, Dirk ;

Sonneveld, Edwin ;

Gibson, Brenda E. S. ;

Pieters, Rob ;

Zimmermann, Martin ;

Zwaan, C. Michel ;

Fornerod, Maarten .

HAEMATOLOGICA, 2015, 100 (09) :1151-1159

[4] Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet [J].

Doehner, Hartmut ;

Estey, Elihu H. ;

Amadori, Sergio ;

Appelbaum, Frederick R. ;

Buechner, Thomas ;

Burnett, Alan K. ;

Dombret, Herve ;

Fenaux, Pierre ;

Grimwade, David ;

Larson, Richard A. ;

Lo-Coco, Francesco ;

Naoe, Tomoki ;

Niederwieser, Dietger ;

Ossenkoppele, Gert J. ;

Sanz, Miguel A. ;

Sierra, Jorge ;

Tallman, Martin S. ;

Loewenberg, Bob ;

Bloomfield, Clara D. .

BLOOD, 2010, 115 (03) :453-474

[5] Molecular characterisation of a recurrent, semi-cryptic RUNX1 translocation t(7;21) in myelodysplastic syndrome and acute myeloid leukaemia [J].

Foster, Nicola ;

Paulsson, Kajsa ;

Sales, Mark ;

Cunningham, Joan ;

Groves, Michael ;

O'Connor, Nigel ;

Begum, Suriya ;

Stubbs, Tracy ;

McMullan, Dominic J. ;

Griffiths, Michael ;

Pratt, Norman ;

Tauro, Sudhir .

BRITISH JOURNAL OF HAEMATOLOGY, 2010, 148 (06) :938-943

[6] Newly emerged isolated Del(7q) in patients with prior cytotoxic therapies may not always be associated with therapy-related myeloid neoplasms [J].

Goswami, Rashmi S. ;

Wang, Sa A. ;

DiNardo, Courtney ;

Tang, Zhenya ;

Li, Yan ;

Zuo, Wenli ;

Hu, Shimin ;

Li, Shaoying ;

Medeiros, L. Jeffrey ;

Tang, Guilin .

MODERN PATHOLOGY, 2016, 29 (07) :727-734

[7] Revised International Prognostic Scoring System for Myelodysplastic Syndromes [J].

Greenberg, Peter L. ;

Tuechler, Heinz ;

Schanz, Julie ;

Sanz, Guillermo ;

Garcia-Manero, Guillermo ;

Sole, Francesc ;

Bennett, John M. ;

Bowen, David ;

Fenaux, Pierre ;

Dreyfus, Francois ;

Kantarjian, Hagop ;

Kuendgen, Andrea ;

Levis, Alessandro ;

Malcovati, Luca ;

Cazzola, Mario ;

Cermak, Jaroslav ;

Fonatsch, Christa ;

Le Beau, Michelle M. ;

Slovak, Marilyn L. ;

Krieger, Otto ;

Luebbert, Michael ;

Maciejewski, Jaroslaw ;

Magalhaes, Silvia M. M. ;

Miyazaki, Yasushi ;

Pfeilstoecker, Michael ;

Sekeres, Mikkael ;

Sperr, Wolfgang R. ;

Stauder, Reinhard ;

Tauro, Sudhir ;

Valent, Peter ;

Vallespi, Teresa ;

van de Loosdrecht, Arjan A. ;

Germing, Ulrich ;

Haase, Detlef .

BLOOD, 2012, 120 (12) :2454-2465

[8] Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group [J].

Heerema, NA ;

Nachman, JB ;

Sather, HN ;

La, MK ;

Hutchinson, R ;

Lange, BJ ;

Bostrom, B ;

Steinherz, PG ;

Gaynon, PS ;

Uckun, FM .

LEUKEMIA, 2004, 18 (05) :939-947

[9] A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42 [J].

Paulsson, K ;

Békássy, AN ;

Olofsson, T ;

Mitelman, F ;

Johansson, B ;

Panagopoulos, I .

LEUKEMIA, 2006, 20 (02) :224-229

[10] Cytogenetic Abnormalities in a Series of 1029 Patients With Primary Myelodysplastic Syndromes A Report From the US With a Focus on Some Undefined Single Chromosomal Abnormalities [J].

Pozdnyakova, Olga ;

Miron, Patricia M. ;

Tang, Guilin ;

Walter, Otto ;

Raza, Azra ;

Woda, Bruce ;

Wang, Sa A. .

CANCER, 2008, 113 (12) :3331-3340

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