Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

被引：20

作者：

Fabiani, Emiliano ^{[1
]}

D'Alo, Francesco ^{[1
]}

Scardocci, Alessandra ^{[1
]}

Greco, Mariangela ^{[1
]}

Di Ruscio, Annalisa ^{[1
]}

Criscuolo, Marianna ^{[1
]}

Fianchi, Luana ^{[1
]}

Pagano, Livio ^{[1
]}

Hohaus, Stefan ^{[1
]}

Leone, Giuseppe ^{[1
]}

Voso, Maria Teresa ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Ist Ematol, I-00168 Rome, Italy

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 08期

关键词：

Myelodysplastic Syndromes; Polymorphisms; Detoxification; DNA repair; Prognosis; GLUTATHIONE-S-TRANSFERASE; ACUTE MYELOID-LEUKEMIA; THERAPY-RELATED LEUKEMIA; INCREASED RISK; MYELODYSPLASTIC SYNDROMES; SUSCEPTIBILITY; CHEMOTHERAPY; INDIVIDUALS; GENOTYPE; PROGNOSIS;

D O I：

10.1016/j.leukres.2008.10.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p = 0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p = 0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1068 / 1071

页数：4

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