Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

被引：20

作者：

Fabiani, Emiliano ^{[1
]}

D'Alo, Francesco ^{[1
]}

Scardocci, Alessandra ^{[1
]}

Greco, Mariangela ^{[1
]}

Di Ruscio, Annalisa ^{[1
]}

Criscuolo, Marianna ^{[1
]}

Fianchi, Luana ^{[1
]}

Pagano, Livio ^{[1
]}

Hohaus, Stefan ^{[1
]}

Leone, Giuseppe ^{[1
]}

Voso, Maria Teresa ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Ist Ematol, I-00168 Rome, Italy

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 08期

关键词：

Myelodysplastic Syndromes; Polymorphisms; Detoxification; DNA repair; Prognosis; GLUTATHIONE-S-TRANSFERASE; ACUTE MYELOID-LEUKEMIA; THERAPY-RELATED LEUKEMIA; INCREASED RISK; MYELODYSPLASTIC SYNDROMES; SUSCEPTIBILITY; CHEMOTHERAPY; INDIVIDUALS; GENOTYPE; PROGNOSIS;

D O I：

10.1016/j.leukres.2008.10.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p = 0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p = 0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1068 / 1071

页数：4

共 30 条

[1] Regulation of JNK signaling by GSTp [J].

Adler, V ;

Yin, ZM ;

Fuchs, SY ;

Benezra, M ;

Rosario, L ;

Tew, KD ;

Pincus, MR ;

Sardana, M ;

Henderson, CJ ;

Wolf, CR ;

Davis, RJ ;

Ronai, Z .

EMBO JOURNAL, 1999, 18 (05) :1321-1334

[2] Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy [J].

Allan, JM ;

Smith, AG ;

Wheatley, K ;

Hills, RK ;

Travis, LB ;

Hill, DA ;

Swirsky, DM ;

Morgan, GJ ;

Wild, CP .

BLOOD, 2004, 104 (13) :3872-3877

[3] Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia [J].

Allan, JM ;

Wild, CP ;

Rollinson, S ;

Willett, EV ;

Moorman, AV ;

Dovey, GJ ;

Roddam, PL ;

Roman, E ;

Cartwright, RA ;

Morgan, GJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) :11592-11597

[4] Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects [J].

Arruda, VR ;

Lima, CSP ;

Grignoli, CRE ;

de Melo, MB ;

Lorand-Metze, I ;

Alberto, FL ;

Saad, STO ;

Costa, FF .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2001, 66 (06) :383-388

[5] The GST deletions and NQO1*2 polymorphism confers interindividual variability of response to treatment in patients with acute myeloid leukemia [J].

Barragan, Eva ;

Collado, Maria ;

Cervera, Jose ;

Martin, Guillermo ;

Bolufer, Pascual ;

Roman, Jose ;

Sanz, Miguel A. .

LEUKEMIA RESEARCH, 2007, 31 (07) :947-953

[6] DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Oncology Group [J].

Bhatla, D. ;

Gerbing, R. B. ;

Alonzo, T. A. ;

Mehta, P. A. ;

Deal, K. ;

Elliott, J. ;

Meshinchi, S. ;

Geiger, H. ;

Perentesis, J. P. ;

Lange, B. J. ;

Davies, S. M. .

LEUKEMIA, 2008, 22 (02) :265-272

[7] Profile of polymorphisms of drug-metabolising enzymes and the risk of therapy-related leukaemia [J].

Bolufer, Pascual ;

Collado, Maria ;

Barragan, Eva ;

Calasanz, Maria-Jose ;

Colomer, Dolors ;

Tormo, Mar ;

Gonzalez, Marcos ;

Brunet, Salut ;

Batlle, Montserrat ;

Cervera, Jose ;

Sanz, Miguel-Angel .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 136 (04) :590-596

[8] Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma [J].

Broberg, Karin ;

Hoglund, Mattias ;

Gustafsson, Cecilia ;

Bjork, Jonas ;

Ingvar, Christian ;

Albin, Maria ;

Olsson, Hakan .

CANCER LETTERS, 2007, 258 (01) :38-44

[9] Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect [J].

Chen, HW ;

Sandler, DP ;

Taylor, JA ;

Shore, DL ;

Liu, E ;

Bloomfield, CD ;

Bell, DA .

LANCET, 1996, 347 (8997) :295-297

[10] Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression [J].

Coles, BF ;

Morel, F ;

Rauch, C ;

Huber, WW ;

Yang, M ;

Teitel, CH ;

Green, B ;

Lang, NP ;

Kadlubar, FF .

PHARMACOGENETICS, 2001, 11 (08) :663-669

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