Gene expression profile of idiopathic thrombocytopenic purpura (ITP)

被引：16

作者：

Sood, Ruchira

Wong, Wendy

Jeng, Michael

Zehnder, James L.

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA

来源：

PEDIATRIC BLOOD & CANCER | 2006年 / 47卷 / 05期

关键词：

interferon; microarray; thrombocytopenia;

D O I：

10.1002/pbc.20981

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To search for novel mechanisms that contribute to the pathophysiology of idiopathic thrombocytopenic purpura (ITP), we determined the whole blood gene expression profile in five ITP patients and five control samples. Using DNA microarrays that contained 24,473 unique putative genes, we found 176 cDNAs that were strongly correlated with ITP. These included a cluster of interferon-regulated genes and TLR7, as well many less-well characterized genes which are candidates for further study. We believe this approach is likely to yield new insights into our understanding of the molecular pathophysiology of ITP. Pediatr Blood Cancer 2006;47:675-677. (c) 2006 Wiley-Liss, Inc.

引用

收藏

页码：675 / 677

页数：3

相关论文

共 15 条

[1]

ABDI EA, 1986, JAMA-J AM MED ASSOC, V255, P1878, DOI 10.1001/jama.1986.03370140076016

[2] Autoimmune thrombocytopenia [J].

Chong, BH ;

Ho, SJ .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2005, 3 (08) :1763-1772

[3] How I treat idiopathic thrombocytopenic purpura (ITP) [J].

Cines, DB ;

Bussel, JB .

BLOOD, 2005, 106 (07) :2244-2251

[4] Cluster analysis and display of genome-wide expression patterns [J].

Eisen, MB ;

Spellman, PT ;

Brown, PO ;

Botstein, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868

[5] Idiopathic cyclic thrombocytopenia [J].

Go, RS .

BLOOD REVIEWS, 2005, 19 (01) :53-59

[6] Expression patterns of Th1 and Th2 cytokine genes in childhood idiopathic thrombocytopenic purpura (ITP) at presentation and their modulation by intravenous immunoglobulin G (IVIg) treatment: their role in prognosis [J].

Mouzaki, A ;

Theodoropoulou, M ;

Gianakopoulos, I ;

Vlaha, V ;

Kyrtsonis, MC ;

Maniatis, A .

BLOOD, 2002, 100 (05) :1774-1779

[7] T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura [J].

Olsson, B ;

Andersson, PO ;

Jernås, M ;

Jacobsson, S ;

Carlsson, B ;

Carlsson, LMS ;

Wadenvik, H .

NATURE MEDICINE, 2003, 9 (09) :1123-1124

[8] Brief report - Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response [J].

Panitsas, FP ;

Theodoropoulou, M ;

Kouraklis, A ;

Karakantza, M ;

Theodorou, GL ;

Zoumbos, NC ;

Maniatis, A ;

Mouzaki, A .

BLOOD, 2004, 103 (07) :2645-2647

[9] U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7 [J].

Savarese, E ;

Chae, OW ;

Trowitzsch, S ;

Weber, G ;

Kastner, B ;

Akira, S ;

Wagner, H ;

Schmid, RM ;

Bauer, S ;

Krug, A .

BLOOD, 2006, 107 (08) :3229-3234

[10] Early detection of breast cancer based on gene-expression patterns in peripheral blood cells [J].

Sharma, P ;

Sahni, NS ;

Tibshirani, R ;

Skaane, P ;

Urdal, P ;

Berghagen, H ;

Jensen, M ;

Kristiansen, L ;

Moen, C ;

Sharma, P ;

Zaka, A ;

Arnes, J ;

Sauer, T ;

Akslen, LA ;

Schlichting, E ;

Borresen-Dale, AL ;

Lönneborg, A .

BREAST CANCER RESEARCH, 2005, 7 (05) :R634-R644