Novel promising stroke therapy: new pharmacological and laser stimulation of brain clearance

被引:0
作者
Semyachkina-Glushkovskaya, O. [1 ]
Klimova, M. [1 ]
Torres, E. Duarte [1 ]
Khorovodov, A. [1 ]
Terskov, A. [1 ]
Mamedova, A. [1 ]
Shareef, A. E. [1 ]
Saranceva, E. [1 ]
Iskra, T. [1 ]
Pavlov, A. [1 ,2 ]
Kurths, J. [1 ,3 ,4 ]
机构
[1] Saratov NG Chernyshevskii State Univ, Astrakhanskaya Str 83, Saratov 410012, Russia
[2] Yuri Gagarin State Tech Univ Saratov, Politech Skaya Str 77, Saratov 410054, Russia
[3] Potsdam Inst Climate Impact Res, Telegraphenberg A 31, D-14473 Potsdam, Germany
[4] Humboldt Univ, Inst Phys, Newtonstr 15, D-12489 Berlin, Germany
来源
BIOPHOTONICS AND IMMUNE RESPONSES XIV | 2019年 / 10879卷
基金
俄罗斯科学基金会;
关键词
stroke; cytotoxic and vasogenic edema; new drugs; aquaporin; blood-brain barrier; matrix metalloproteinase; vascular endothelial growth factor; Sulfonylurea receptor 1; ENDOTHELIAL GROWTH-FACTOR; MATRIX METALLOPROTEINASES; EDEMA FORMATION; BARRIER DISRUPTION; AQUAPORIN-4; ISCHEMIA; INJURY; MATRIX-METALLOPROTEINASE-9; NEUROPROTECTION; PERMEABILITY;
D O I
10.1117/12.2508259
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Stroke and traumatic brain injury are often associated with formation of brain edema, which is a potentially fatal pathological state provoking extensive accumulation of fluid in the brain tissues resulting in elevation of intracranial pressure and leading to impaired nerve function. There is only symptomatic anti-edema therapy is currently available. Therefore, the development of novel strategies to remove edema fluid is required. The brain edema is classified as vasogenic or cytotoxic edema, which associated with excess accumulation of fluid (edema) around capillaries resulting from disruption of the blood-brain barrier (BBB) or intracellular spaces (cell swelling) of the brain, respectively. In this brief review, we discuss possible mechanisms underlying brain edema formation and new strategies in development of novel of anti-edema drugs.
引用
收藏
页数:6
相关论文
共 46 条
  • [1] [Anonymous], 2018, Global Health Estimates 2016 (Deaths by Cause, Age, Sex, by Country and by Region, 20002016
  • [2] and Life Expectancy, 20002016)
  • [3] Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia
    Asahi, M
    Wang, XY
    Mori, T
    Sumii, T
    Jung, JC
    Moskowitz, MA
    Fini, ME
    Lo, EH
    [J]. JOURNAL OF NEUROSCIENCE, 2001, 21 (19) : 7724 - 7732
  • [4] Pericytes Contribute to the Disruption of the Cerebral Endothelial Barrier via Increasing VEGF Expression: Implications for Stroke
    Bai, Ying
    Zhu, Xinjian
    Chao, Jie
    Zhang, Yuan
    Qian, Cheng
    Li, Peicheng
    Liu, Dongfang
    Han, Bing
    Zhao, Lei
    Zhang, Jianqiong
    Buch, Shilpa
    Teng, Gaojun
    Hu, Gang
    Yao, Honghong
    [J]. PLOS ONE, 2015, 10 (04):
  • [5] Treatment of Malignant Brain Edema and Increased Intracranial Pressure After Stroke
    Brogan, Michael E.
    Manno, Edward M.
    [J]. CURRENT TREATMENT OPTIONS IN NEUROLOGY, 2015, 17 (01) : 1 - 11
  • [6] Calcium modulation of adherens and tight junction function - A potential mechanism for blood-brain barrier disruption after stroke
    Brown, RC
    Davis, TP
    [J]. STROKE, 2002, 33 (06) : 1706 - 1711
  • [7] Dostovic Zikrija, 2016, Med Arch, V70, P339
  • [8] Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010
    Feigin, Valery L.
    Forouzanfar, Mohammad H.
    Krishnamurthi, Rita
    Mensah, George A.
    Connor, Myles
    Bennett, Derrick A.
    Moran, Andrew E.
    Sacco, Ralph L.
    Anderson, Laurie
    Truelsen, Thomas
    O'Donnell, Martin
    Venketasubramanian, Narayanaswamy
    Barker-Collo, Suzanne
    Lawes, Carlene M. M.
    Wang, Wenzhi
    Shinohara, Yukito
    Witt, Emma
    Ezzati, Majid
    Naghavi, Mohsen
    Murray, Christopher
    [J]. LANCET, 2014, 383 (9913) : 245 - 255
  • [9] LARGE HEMISPHERIC INFARCTION, DETERIORATION, AND INTRACRANIAL-PRESSURE
    FRANK, JI
    [J]. NEUROLOGY, 1995, 45 (07) : 1286 - 1290
  • [10] 'Malignant' middle cerebral artery territory infarction - Clinical course and prognostic signs
    Hacke, W
    Schwab, S
    Horn, M
    Spranger, M
    DeGeorgia, M
    vonKummer, R
    [J]. ARCHIVES OF NEUROLOGY, 1996, 53 (04) : 309 - 315