Green synthesis of antimicrobial and antitumor N,N,N-trimethyl chitosan chloride/poly (acrylic acid)/silver nanocomposites

被引：31
作者：
Abu Elella, Mahmoud H. [1 ]
Mohamed, Riham R. [1 ]
Abdel-Aziz, Marwa M. [2 ]
Sabaa, Magdy W. [1 ]
机构：
[1] Cairo Univ, Chem Dept, Fac Sci, Giza 12613, Egypt
[2] Al Azhar Univ, Reg Ctr Mycol & Biotechnol, Cairo 11651, Egypt
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 111卷
关键词：
N; N-trimethyl chitosan chloride; Poly(acrylic acid); Polyelectrolyte complex; Nanocomposites; Antimicrobial activity; SILVER NANOPARTICLES; POLYELECTROLYTE COMPLEX; ANTIBACTERIAL ACTIVITY; COLORECTAL-CANCER; HYDROGEL BEADS; CYTOTOXICITY; DERIVATIVES; ADSORPTION; BEHAVIOR; FILMS;
D O I：
10.1016/j.ijbiomac.2018.01.055
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present study is imported to solve two critical problems we face in our daily life which are microbial pollution and colon cancer. One pot green synthesis of a water soluble polyelectrolyte complex (PEC) between cationic polysaccharide as N,N,N-trimethyl chitosan chloride (TMC) and anionic polymer as poly (acrylic acid) (PAA) in presence of silver nanoparticles to yield (TMC/PAA/Ag) nanocomposites with different Ag weight ratios. Structure of TMC, PAA and TMC/PAA (PEC) were proved via different analysis tools. TMC/PAA and its Ag nanocomposites are used as antimicrobial agents against different pathogenic bacteria and fungi to solve microbial pollution. TMC/PAA-Silver nanocomposites had the highest antimicrobial activity which increases with increasing Ag %. Cytotoxicity data confirmed also that TMC/PAA/Ag (3%) had the most cytotoxic effect (the less cell viability %) towards colon cancer. TMC/PAA (PEC) was formed through electrostatic interactions between N-quaternized (-N+ R-3) groups in TMC and carboxylate (-COO-) groups in PAA. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：706 / 716
页数：11
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