Benign and efficient synthesis of 2-substituted 4(3H)-quinazolinones mediated by iron(III) chloride hexahydrate in refluxing water

被引：62

作者：

Wang, Guan-Wu ^{[1
]}

Miao, Chun-Bao

Kang, Hui

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2006年 / 79卷 / 09期

关键词：

D O I：

10.1246/bcsj.79.1426

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Condensation of aldehydes with anthranilamide in refluxing water using iron(III) chloride hexahydrate as an oxidiant afforded 2-substituted 4(3H)-quinazolinones in good yields (77-93%). This method provides several advantages such as being environmentally friendly, having a simple work-up procedure, and affording high yields.

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页码：1426 / 1430

页数：5

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