Chronic L-DOPA treatment increases striatal cannabinoid CB1 receptor mRNA expression in 6-hydroxydopamine-lesioned rats

被引：58

作者：

Zeng, BY ^{[1
]}

Dass, B ^{[1
]}

Owen, A ^{[1
]}

Rose, S ^{[1
]}

Cannizzaro, C ^{[1
]}

Tel, BC ^{[1
]}

Jenner, P ^{[1
]}

机构：

[1] Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, Div Pharmacol & Therapeut, Neurodegenerat Dis Res Ctr, London SW3 6LX, England

来源：

NEUROSCIENCE LETTERS | 1999年 / 276卷 / 02期

关键词：

cannabinoid CB1 receptor mRNA; L-DOPA; 6-hydroxydopamine; striatum; subthalamic nucleus;

D O I：

10.1016/S0304-3940(99)00762-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of a unilateral g-hydroxydopamine (6-OHDA) lesion of the left medial forebrain bundle and 3 weeks treatment with L-DOPA of normal and 6-OHDA lesioned rats on CB1r mRNA expression was investigated by in situ hybridization. A 6-OHDA lesion of nigrostriatal pathway alone, confirmed by the loss of nigral tyrosine hydroxylase mRNA, did not alter CB1r mRNA levels in the dopamine depleted striatum. Similarly, chronic L-DOPA treatment of normal rats had no effect on striatal CB1r mRNA expression. In contrast, chronic L-DOPA treatment of 6-OHDA-lesioned rats significantly increased CB1r mRNA expression in the denervated striatum. These results suggest that the CB1r activity may be altered by L-DOPA's action and this may be related to the treatment of Parkinson's disease. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：71 / 74

页数：4

共 21 条

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