eDIFFERENTIAL EFFECTS OF ACUTE STRESS ON ANTICIPATORY AND CONSUMMATORY PHASES OF REWARD PROCESSING

被引:101
作者
Kumar, P. [1 ,2 ]
Berghorst, L. H. [3 ]
Nickerson, L. D. [2 ,4 ]
Dutra, S. J. [5 ]
Goer, F. K. [1 ]
Greve, D. N. [6 ]
Pizzagalli, D. A. [1 ,2 ,4 ]
机构
[1] McLean Hosp, Ctr Depress Anxiety & Stress Res, Belmont, MA 02478 USA
[2] Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA
[3] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA
[4] McLean Hosp, McLean Imaging Ctr, Belmont, MA 02478 USA
[5] Yale Univ, Dept Psychol, New Haven, CT 06520 USA
[6] Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA USA
关键词
stress; basal ganglia; reward; anticipation; consumption; monetary incentive delay; STRIATAL DOPAMINE RELEASE; NUCLEUS-ACCUMBENS; HEALTHY-MEN; INDIVIDUAL-DIFFERENCES; ORBITOFRONTAL CORTEX; PSYCHOSOCIAL STRESS; INCENTIVE SALIENCE; HEDONIC CAPACITY; HUMAN COGNITION; LIFE EVENTS;
D O I
10.1016/j.neuroscience.2014.01.058
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Anhedonia is one of the core symptoms of depression and has been linked to blunted responses to rewarding stimuli in striatal regions. Stress, a key vulnerability factor for depression, has been shown to induce anhedonic behavior, including reduced reward responsiveness in both animals and humans, but the brain processes associated with these effects remain largely unknown in humans. Emerging evidence suggests that stress has dissociable effects on distinct components of reward processing, as it has been found to potentiate motivation/`wanting' during the anticipatory phase but reduce reward responsiveness/ `liking' during the consummatory phase. To examine the impact of stress on reward processing, we used a monetary incentive delay (MID) task and an acute stress manipulation (negative performance feedback) in conjunction with functional magnetic resonance imaging (fMRI). Fifteen healthy participants performed the MID task under no-stress and stress conditions. We hypothesized that stress would have dissociable effects on the anticipatory and consummatory phases in reward-related brain regions. Specifically, we expected reduced striatal responsiveness during reward consumption (mirroring patterns previously observed in clinical depression) and increased striatal activation during reward anticipation consistent with non-human findings. Supporting our hypotheses, significant Phase (Anticipation/ Consumption) x Stress (Stress/No-stress) interactions emerged in the putamen, nucleus accumbens, caudate and amygdala. Post hoc tests revealed that stress increased striatal and amygdalar activation during anticipation but decreased striatal activation during consumption. Importantly, stress-induced striatal blunting was similar to the profile observed in clinical depression under baseline (no-stress) conditions in prior studies. Given that stress is a pivotal vulnerability factor for depression, these results offer insight to better understand the etiology of this prevalent disorder. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1 / 12
页数:12
相关论文
共 71 条
[1]   DIFFERENTIAL EFFECT OF STRESS ON INVIVO DOPAMINE RELEASE IN STRIATUM, NUCLEUS ACCUMBENS, AND MEDIAL FRONTAL-CORTEX [J].
ABERCROMBIE, ED ;
KEEFE, KA ;
DIFRISCHIA, DS ;
ZIGMOND, MJ .
JOURNAL OF NEUROCHEMISTRY, 1989, 52 (05) :1655-1658
[2]   Effects of acute metabolic stress on striatal dopamine release in healthy volunteers [J].
Adler, CM ;
Elman, I ;
Weisenfeld, N ;
Kestler, L ;
Pickar, D ;
Breier, A .
NEUROPSYCHOPHARMACOLOGY, 2000, 22 (05) :545-550
[3]   Stress, depression, and anhedonia: Caveats concerning animal models [J].
Anisman, H ;
Matheson, K .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2005, 29 (4-5) :525-546
[4]  
[Anonymous], 2002, STRUCTURED CLIN INTE
[5]   Neurochemistry of Stress. An Overview [J].
Baumann, Nicole ;
Turpin, Jean-Claude .
NEUROCHEMICAL RESEARCH, 2010, 35 (12) :1875-1879
[6]   THE EFFECT OF STRESS ON HEDONIC CAPACITY [J].
BERENBAUM, H ;
CONNELLY, J .
JOURNAL OF ABNORMAL PSYCHOLOGY, 1993, 102 (03) :474-481
[7]   Acute stress selectively reduces reward sensitivity [J].
Berghorst, Lisa H. ;
Bogdan, Ryan ;
Frank, Michael J. ;
Pizzagalli, Diego A. .
FRONTIERS IN HUMAN NEUROSCIENCE, 2013, 7
[8]   What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? [J].
Berridge, KC ;
Robinson, TE .
BRAIN RESEARCH REVIEWS, 1998, 28 (03) :309-369
[9]   From prediction error to incentive salience: mesolimbic computation of reward motivation [J].
Berridge, Kent C. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2012, 35 (07) :1124-1143
[10]   Dissecting components of reward: 'liking', 'wanting', and learning [J].
Berridge, Kent C. ;
Robinson, Terry E. ;
Aldridge, J. Wayne .
CURRENT OPINION IN PHARMACOLOGY, 2009, 9 (01) :65-73