Effect of oral anticoagulants on the outcome of faecal immunochemical test

被引：30

作者：

Bujanda, L. ^{[1
]}

Sarasqueta, C. ^{[2
]}

Lanas, A. ^{[3
]}

Quintero, E. ^{[4
]}

Cubiella, J. ^{[5
]}

Hernandez, V. ^{[6
]}

Morillas, J. D. ^{[7
]}

Perez-Fernandez, T. ^{[8
]}

Salas, D. ^{[9
]}

Andreu, M. ^{[10
]}

Carballo, F. ^{[11
]}

Bessa, X. ^{[10
]}

Portillo, I. ^{[12
]}

Jover, R. ^{[13
]}

Balaguer, F. ^{[14
]}

Cosme, A. ^{[1
]}

Castells, A. ^{[14
]}

机构：

[1] Univ Pais Vasco UPV EHU, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Hosp Univ Donostia, Dept Gastroenterol,Inst Biodonostia, San Sebastian, Spain

[2] Hosp Univ Donostia, Inst Biodonostia, Red Invest Serv Salud Enfermedades Cron REDISSEC, San Sebastian, Spain

[3] Univ Zaragoza, Dept Gastroenterol, IIS Aragon, CIBERehd, Zaragoza, Spain

[4] Univ La Laguna, Hosp Univ Canarias, Dept Gastroenterol, Tenerife, Spain

[5] Complexo Hosp Univ Ourense, Dept Gastroenterol, Orense, Spain

[6] Complexo Hosp Univ Vigo, Serv Aparato Digest, Vigo, Spain

[7] Hosp Clin San Carlos, Dept Gastroenterol, Madrid, Spain

[8] Hosp Fdn Alcorcon, Dept Gastroenterol, Madrid, Spain

[9] Conselleria Sanitat, Programa Cribado Canc Colorrectal, Direcc Gen Salud Publ, Valencia, Spain

[10] IMIM, Hosp del Mar, Dept Gastroenterol, Barcelona, Catalonia, Spain

[11] Hosp Univ Virgen de la Arrixaca, Unidad Gest Clin Digest, Murcia, Spain

[12] Org Cent Osakidetza Serv Vasco Salud, Programa Cribado Canc Colorrectal, Bilbao, Spain

[13] Hosp Gen Univ Alicante, Dept Gastroenterol, Alicante, Spain

[14] Univ Barcelona, IDIBAPS, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Dept Gastroenterol,Hosp Clin, Barcelona, Catalonia, Spain

来源：

BRITISH JOURNAL OF CANCER | 2014年 / 110卷 / 05期

关键词：

faecal immunochemical test; FIT; oral anticoagulant; advanced neoplasia; colorectal cancer screening; OCCULT BLOOD-TEST; LOW-DOSE ASPIRIN; COLORECTAL-CANCER; COLONOSCOPY; WARFARIN; DRUGS;

D O I：

10.1038/bjc.2014.38

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml(-1)) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend = 0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P = 0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P = 0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.

引用

页码：1334 / 1337

页数：4

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