Allergies and childhood leukemia

被引：10
作者：
Chang, Jeffrey S. [1 ]
Wiemels, Joseph L. [1 ]
Buffler, Patricia A. [2 ]
机构：
[1] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
[2] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA
来源：
BLOOD CELLS MOLECULES AND DISEASES | 2009年 / 42卷 / 02期
关键词：
Childhood leukemia; Allergy; Immune function; ACUTE LYMPHOBLASTIC-LEUKEMIA; DAY-CARE ATTENDANCE; NEONATAL IMMUNE-RESPONSES; TOLL-LIKE RECEPTORS; MATERNAL SMOKING; BIRTH-ORDER; CHROMOSOME TRANSLOCATIONS; ATOPIC DISEASE; SIBSHIP SIZE; RISK-FACTORS;
D O I：
10.1016/j.bcmd.2008.10.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A majority of studies to date have reported an inversed association between allergies and childhood leukemia. However, this association is likely an indirect one and may represent some shared underlying immune mechanisms that have been explained in the context of the "hygiene hypothesis", which has been thought to play an important role in the development of both allergies and childhood leukemia. This review focuses on what we know so far about the role of various immune cells (Th1, Th2, T regulatory and Th17 cells) in the development of allergies and how they may potentially be related to the etiology of childhood leukemia. In addition, the utilities of genetic and molecular studies to disentangle the association between allergies and childhood leukemia and to elucidate the biological mechanisms are also discussed. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：99 / 104
页数：6
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