Colloidal drug delivery system: amplify the ocular delivery

被引:79
作者
Ameeduzzafar [1 ]
Ali, Javed [1 ]
Fazil, Mohd [1 ]
Qumbar, Mohd [1 ]
Khan, Nazia [1 ]
Ali, Asgar [1 ]
机构
[1] Jamia Hamdard, Pharmaceut PhD Lab, Dept Pharmaceut, New Delhi 110062, India
关键词
Colloidal delivery system; eye; nanotechnology; ocular barriers; ocular transporter; pharmacokinetics; IN-VITRO CHARACTERIZATION; BLOOD-RETINAL BARRIER; TEAR FILM; CHITOSAN NANOPARTICLES; P-GLYCOPROTEIN; AQUEOUS-HUMOR; TIMOLOL MALEATE; CONTACT-LENSES; CYCLOSPORINE-A; RABBIT EYE;
D O I
10.3109/10717544.2014.923065
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Context: The ocular perceivers are the most voluntarily accessible organs in terms of location in the body, yet drug distribution to these tissues is one of the most intriguing and challenging endeavors and problematic to the pharmaceutical scientist. The most of ocular diseases are treated with topical application of conventional formulation, i.e. solutions, suspensions and ointment. Typically on installation of these conventional formulations, only <5% of the applied dose penetrates the cornea and reaches intraocular tissues, while a major fraction of the instilled dose is wastage due to the presence of many ocular barriers like external barriers, rapid loss of the instilled solution from the precorneal area and nasolacrimal drainage system. Systemic absorption caused systemic side effects varying from mild to life-threatening events. Objective: The main objective of this review is to explore the role of colloidal delivery of drug to minimize the drawbacks associated with them. Methods: This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings and applications of colloidal delivery systems, i.e. nanoparticles, nanosuspensions, liposomes, niosomes, dendrimers and contact lenses containing nanoparticles have the capacity to distribute ocular drugs to categorical target sites and hold promise to revolutionize the therapy of many ocular perceiver diseases and minimized the circumscription of conventional delivery. Conclusion: Form the basis of literature review, it has been found that the novel delivery system have greater impact to maximize ocular drug absorption, and minimize systemic absorption and side effects.
引用
收藏
页码:710 / 726
页数:17
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